{"id":"W4385658427","doi":"10.1089/scd.2023.0038","title":"Fate Specification of GFAP-Negative Primitive Neural Stem Cells and Their Progeny at Clonal Resolution","year":2023,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"","keywords":"Biology; Neural stem cell; Progenitor cell; Neurosphere; Progenitor; Stem cell; Embryonic stem cell; Cell biology; Lineage (genetic); Glial fibrillary acidic protein; Population; Precursor cell; Immunology; Adult stem cell; Genetics; Cell; Gene; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001843826,0.0001130602,0.0001511876,0.000219745,0.0002277962,0.0004281733,0.0001864656,0.0001747913,0.0005021936],"category_scores_gemma":[0.0002098281,0.0001417221,0.0001189619,0.0001381435,0.0002283599,0.0001654648,0.00021875,0.000439917,0.0003999847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002609043,"about_ca_system_score_gemma":0.0002327061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009221854,"about_ca_topic_score_gemma":0.003554462,"domain_scores_codex":[0.9998895,0.000005748519,0.000007912683,0.00002730416,0.00005460866,0.00001494594],"domain_scores_gemma":[0.9998308,0.00005491315,0.00002785484,0.00002168907,0.00003829248,0.00002640686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000008155094,0.000003219909,0.0003712152,0.000006551603,6.983539e-7,0.00002271186,0.00002983784,0.00004944469,0.9982561,0.0001518909,0.0000158311,0.001084246],"study_design_scores_gemma":[0.000003161239,0.00002591399,0.007375412,0.000006629766,0.000005466045,0.0001599648,0.00007019957,0.001993876,0.9881619,0.0001819117,0.002012615,0.000002935238],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710934,0.0003742957,0.0241297,0.00005836612,0.00001167629,0.00004501014,0.0006957228,0.0001793354,0.003412431],"genre_scores_gemma":[0.9501846,0.0007060555,0.03893762,0.00009025219,0.000008446196,0.000149546,0.001773592,0.0001580541,0.007991709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009221854,"threshold_uncertainty_score":0.001892984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02959215086751604,"score_gpt":0.2167317190940228,"score_spread":0.1871395682265068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}