{"id":"W4385658427","doi":"10.1089/scd.2023.0038","title":"Fate Specification of GFAP-Negative Primitive Neural Stem Cells and Their Progeny at Clonal Resolution","year":2023,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"","keywords":"Biology; Neural stem cell; Progenitor cell; Neurosphere; Progenitor; Stem cell; Embryonic stem cell; Cell biology; Lineage (genetic); Glial fibrillary acidic protein; Population; Precursor cell; Immunology; Adult stem cell; Genetics; Cell; Gene; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993971,0.0001538295,0.0001486925,0.00004575766,0.0001192208,0.00001576856,0.00006133662,0.0001011717,0.000002869457],"category_scores_gemma":[0.000001121665,0.0001281643,0.00003190498,0.00008115846,0.00008925164,0.000004574901,0.00009433577,0.00005037626,0.00000584838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002772207,"about_ca_system_score_gemma":0.0000541484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005837189,"about_ca_topic_score_gemma":0.00003036643,"domain_scores_codex":[0.9990705,0.00004032412,0.0002593087,0.000320715,0.0001080156,0.000201182],"domain_scores_gemma":[0.9996175,0.00002318856,0.0001016138,0.0001064785,0.00007847087,0.00007278227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001689158,0.00003129202,0.001364688,0.00007228368,0.00004421981,0.000001658897,0.0014033,0.00002683695,0.9813978,0.0000211358,0.0001510074,0.01531686],"study_design_scores_gemma":[0.0004266558,0.0001138791,0.01087516,0.00002127237,0.000005888614,0.000003169224,0.000590921,0.0002375861,0.9787595,0.000008125357,0.008800136,0.0001576939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980163,0.0003995073,0.000748497,0.00002626104,0.0001498302,0.0003004853,0.00005793621,0.00001440136,0.0002867643],"genre_scores_gemma":[0.9977395,0.000471906,0.0006458774,0.00003391245,0.00004253682,0.00001494326,0.00006113368,0.00001541318,0.0009747698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01515917,"threshold_uncertainty_score":0.5226387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02959215086751604,"score_gpt":0.2167317190940228,"score_spread":0.1871395682265068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}