{"id":"W4385658444","doi":"10.3233/adr-230081","title":"Uncovering Diverse Mechanistic Spreading Pathways in Disease Progression of Alzheimer’s Disease","year":2023,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Canadian Institutes of Health Research; Foundation of Hope for Research and Treatment of Mental Illness; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; University of Southern California; BioClinica; Bristol-Myers Squibb; Eli Lilly and Company; Biogen","keywords":"Neurodegeneration; Disease; Biomarker; Neuroscience; Cognitive decline; Mechanism (biology); Cognition; Amyloid (mycology); Pathological; Biology; Alzheimer's disease; Psychology; Dementia; Medicine; Bioinformatics; Internal medicine; Genetics; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004001511,0.0005204082,0.0005196616,0.001172289,0.0003651748,0.001077041,0.0006462033,0.0005196084,0.0008313404],"category_scores_gemma":[0.005915164,0.0003207389,0.001273001,0.0008188187,0.0009854706,0.0009709991,0.00114094,0.0009377348,0.0001336525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004779848,"about_ca_system_score_gemma":0.001176331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002238936,"about_ca_topic_score_gemma":0.001948641,"domain_scores_codex":[0.9992835,0.0003743878,0.00003590859,0.0001583979,0.00008752387,0.00006029228],"domain_scores_gemma":[0.9953023,0.002956022,0.0008386365,0.0004430402,0.0002673464,0.0001926535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001263624,0.0005636057,0.5250676,0.0007339515,0.002292164,0.001239654,0.0009560928,0.2501698,0.04126807,0.03684774,0.0009146766,0.1386829],"study_design_scores_gemma":[0.00006134349,0.0005061944,0.2391812,0.00008805437,0.0006492707,0.0006778786,0.00045902,0.6166117,0.005546054,0.1348856,0.00125151,0.00008227491],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8256576,0.001957114,0.1700813,0.0006803932,0.00001767405,0.00006350732,0.0003084769,0.0001655581,0.001068273],"genre_scores_gemma":[0.9791693,0.000509158,0.01983244,0.00006271142,0.00001676654,0.00002782784,0.0001667576,0.00001203248,0.0002030424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004001511,"threshold_uncertainty_score":0.02116227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05679396448358615,"score_gpt":0.3441978434853178,"score_spread":0.2874038790017317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}