{"id":"W4385658445","doi":"10.1089/brain.2023.0013","title":"Structural Network Topology Reveals Higher Brain Resilience in Individuals with Preclinical Alzheimer's Disease","year":2023,"lang":"en","type":"article","venue":"Brain Connectivity","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Assortativity; White matter; Alzheimer's disease; Pathological; Topology (electrical circuits); Hippocampus; Neuroscience; Neuroimaging; Biology; Disease; Psychology; Medicine; Internal medicine; Magnetic resonance imaging; Mathematics; Combinatorics; Complex network","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003170318,0.000357721,0.0002625045,0.001272409,0.0002914754,0.0004433695,0.0002290771,0.0003157029,0.002353284],"category_scores_gemma":[0.001969994,0.0001523972,0.0001899772,0.0006295554,0.000312092,0.0004744735,0.0004820944,0.0002206236,0.0001741814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001994132,"about_ca_system_score_gemma":0.0001195832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001457175,"about_ca_topic_score_gemma":0.001949037,"domain_scores_codex":[0.9998767,0.00002602157,0.00001384792,0.00004228986,0.00002014571,0.00002092384],"domain_scores_gemma":[0.999184,0.000129644,0.0004303479,0.00007314675,0.00006809203,0.0001147148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008112671,0.00009594915,0.9789237,0.0000515237,0.0002934541,0.0003276916,0.0005864043,0.00070946,0.009123705,0.0002838087,0.0002793314,0.008513632],"study_design_scores_gemma":[0.000005183639,0.0001012378,0.9976689,0.000005638143,0.00003431809,0.0004015405,0.0001586241,0.0007874501,0.0002828776,0.0004717775,0.0000776926,0.000004640146],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993856,0.0000544196,0.0001838716,0.00002542751,0.00000169061,0.00000318662,0.0001132878,0.000006633281,0.0002258609],"genre_scores_gemma":[0.9996203,0.00003261254,0.0001363493,0.000004684471,0.000002774303,0.000003608617,0.0001394763,0.000001735755,0.00005834315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002353284,"threshold_uncertainty_score":0.007872522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07219039847702018,"score_gpt":0.3369325578859986,"score_spread":0.2647421594089784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}