{"id":"W4385658467","doi":"10.1097/01.hs9.0000967408.39207.65","title":"S124: PHOSPHOPROTEOMICS ACCURATELY PREDICTS RESPONSES TO MIDOSTAURIN PLUS CHEMOTHERAPY IN TWO INDEPENDENT COHORTS OF FLT3 MUTANT-POSITIVE ACUTE MYELOID LEUKAEMIA","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Midostaurin; Medicine; Myeloid leukemia; Internal medicine; Oncology; Phosphoproteomics; Fms-Like Tyrosine Kinase 3; Refractory (planetary science); Biology; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009401357,0.0004830136,0.001062361,0.0004489034,0.00009514209,0.00004341222,0.000461144,0.0003022798,0.0006443492],"category_scores_gemma":[0.0004748447,0.0004532606,0.0001951271,0.00211586,0.0001909516,0.0001911534,0.0003847401,0.000888289,0.0004131084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001645706,"about_ca_system_score_gemma":0.001922322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00100243,"about_ca_topic_score_gemma":0.000508435,"domain_scores_codex":[0.9958399,0.0001816483,0.0008506681,0.0008799813,0.001178578,0.001069234],"domain_scores_gemma":[0.9976054,0.0003909743,0.0002080324,0.0009184008,0.0003571044,0.0005200485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05153029,0.0006864401,0.1387047,0.000871214,0.001512119,0.01227153,0.0119993,0.001049905,0.7356716,0.000409324,0.02279371,0.02249981],"study_design_scores_gemma":[0.01435456,0.001078867,0.2084784,0.0009904251,0.0001158185,0.0004294106,0.00215188,0.002237984,0.767931,0.0001879105,0.0014486,0.0005951149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911741,0.0002154577,0.0001433468,0.002569955,0.0001719901,0.003111438,0.0002132012,0.0002427713,0.00215773],"genre_scores_gemma":[0.9884155,0.0008075116,0.001775514,0.0008268785,0.0001751631,0.0003230497,0.0001367386,0.0001568538,0.007382728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06977373,"threshold_uncertainty_score":0.9997919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03026132936396408,"score_gpt":0.3435764329594033,"score_spread":0.3133151035954392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}