{"id":"W4385658467","doi":"10.1097/01.hs9.0000967408.39207.65","title":"S124: PHOSPHOPROTEOMICS ACCURATELY PREDICTS RESPONSES TO MIDOSTAURIN PLUS CHEMOTHERAPY IN TWO INDEPENDENT COHORTS OF FLT3 MUTANT-POSITIVE ACUTE MYELOID LEUKAEMIA","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Midostaurin; Medicine; Myeloid leukemia; Internal medicine; Oncology; Phosphoproteomics; Fms-Like Tyrosine Kinase 3; Refractory (planetary science); Biology; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007657686,0.0006219776,0.0006039036,0.0006086363,0.0002268666,0.0007344941,0.00038552,0.0004668999,0.001042662],"category_scores_gemma":[0.001241726,0.0002039494,0.0007896913,0.0003059265,0.0002210289,0.0003676969,0.0005265433,0.0004839318,0.000331809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005977713,"about_ca_system_score_gemma":0.0003933274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001954474,"about_ca_topic_score_gemma":0.001871286,"domain_scores_codex":[0.9998136,0.00004527283,0.00001524024,0.00007054882,0.00002802286,0.00002733739],"domain_scores_gemma":[0.9995881,0.0001518412,0.0001169172,0.00003971981,0.00003515146,0.00006832999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002879152,0.0002571696,0.951171,0.00004135244,0.0003204857,0.0002288454,0.0001303021,0.01931883,0.01185556,0.0000642461,0.0004288017,0.01330429],"study_design_scores_gemma":[0.0001076156,0.001268029,0.7863738,0.00001429934,0.0003072163,0.0008781693,0.0002215951,0.2031354,0.006340699,0.0004958246,0.0008264252,0.00003083915],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986293,0.000063042,0.0007723022,0.00003887111,0.000003128581,0.00001375207,0.0003581952,0.00001389113,0.0001076558],"genre_scores_gemma":[0.998355,0.00002872932,0.0004075145,0.00001123761,0.000003242431,0.00001354341,0.001101152,0.000002942261,0.00007677066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001954474,"threshold_uncertainty_score":0.004337192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03026132936396408,"score_gpt":0.3435764329594033,"score_spread":0.3133151035954392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}