{"id":"W4385666735","doi":"10.1165/rcmb.2022-0457oc","title":"Oxidized Phosphatidylcholines Trigger TRPA1 and Ryanodine Receptor–dependent Airway Smooth Muscle Contraction","year":2023,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of British Columbia; University of Manitoba; Children's Hospital Research Institute of Manitoba; Research Manitoba","funders":"Children's Hospital Research Institute of Manitoba; Canada Research Chairs; Canadian Lung Association; Research Manitoba","keywords":"Ryanodine receptor; Intracellular; Chemistry; Endoplasmic reticulum; Extracellular; Fura-2; Myosin light-chain kinase; Biophysics; Internal medicine; Cell biology; Myosin; Endocrinology; Biochemistry; Biology; Cytosol; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004422071,0.0001717528,0.0003804876,0.0002431457,0.0001236146,0.00002831481,0.0001298686,0.00008085237,0.00003952174],"category_scores_gemma":[0.0001992503,0.0001268701,0.00009717566,0.0003293121,0.0004354099,0.00008163398,0.00005414322,0.0002305737,0.00001353423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001724697,"about_ca_system_score_gemma":0.00005824912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001250764,"about_ca_topic_score_gemma":9.341122e-7,"domain_scores_codex":[0.9985089,0.0003698278,0.0003933245,0.0002936155,0.0001562442,0.0002781374],"domain_scores_gemma":[0.9989811,0.0001802978,0.0004765346,0.00009272731,0.00008207348,0.0001872208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001264334,0.00003847068,0.00009572889,0.000007037195,0.000008768262,0.00004515384,0.00009908126,0.00001563704,0.9617897,0.00004806251,0.0003954174,0.03733046],"study_design_scores_gemma":[0.001332479,0.001132599,0.0001594575,0.00001361762,0.00002096577,0.00003143411,0.0002644937,0.00002593239,0.877461,0.00006716044,0.1193236,0.0001672404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968251,0.001093656,0.0004718515,0.0006376815,0.0006982976,0.0001089375,0.000009437572,0.00002632192,0.000128735],"genre_scores_gemma":[0.9956153,0.002428675,0.00009710266,0.001538198,0.000159859,0.000004265445,0.000001404059,0.0000207332,0.0001344554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1189282,"threshold_uncertainty_score":0.5173614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570695893449272,"score_gpt":0.2754472933940382,"score_spread":0.2597403344595455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}