{"id":"W4385667083","doi":"10.1097/01.hs9.0000967892.54405.ff","title":"S245: RUXOLITINIB IN PEDIATRIC PATIENTS WITH TREATMENT-NAIVE OR STEROID-REFRACTORY CHRONIC GRAFT VERSUS HOST DISEASE: PRIMARY FINDINGS FROM THE PHASE II REACH5 STUDY","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Ruxolitinib; Clinical endpoint; Refractory (planetary science); Graft-versus-host disease; Internal medicine; Transplantation; Calcineurin; Hematopoietic stem cell transplantation; Phases of clinical research; Gastroenterology; Clinical trial; Surgery; Bone marrow; Myelofibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300709,0.0003453323,0.0004409125,0.00009104254,0.0001741512,0.00002546988,0.0001485476,0.00008771496,0.0005680741],"category_scores_gemma":[0.00006057775,0.0002069721,0.00008282853,0.0006528995,0.00005711723,0.0001390872,0.00004555371,0.0002166013,0.0001891016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00054442,"about_ca_system_score_gemma":0.0005017683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001815002,"about_ca_topic_score_gemma":0.0005085868,"domain_scores_codex":[0.9978312,0.0001236149,0.0004135509,0.0005547535,0.0006137653,0.0004630837],"domain_scores_gemma":[0.9983658,0.0006460627,0.0001205576,0.0005665961,0.00006434644,0.0002366851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01062447,0.004980583,0.9715865,0.0003429513,0.0002538473,0.0009974051,0.007836703,0.000004998009,0.0001224046,0.000004737313,0.001015246,0.002230145],"study_design_scores_gemma":[0.05028934,0.007498919,0.9376156,0.0002616819,0.0009461594,0.000002039522,0.002176148,0.00002344597,0.00007564034,0.000003346517,0.0008461488,0.0002615429],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957215,0.0004699373,0.000004739505,0.0001920802,0.0002307281,0.002427433,0.0003041405,0.0001615559,0.000487893],"genre_scores_gemma":[0.9965245,0.0002406805,0.00004310371,0.00006862359,0.0002624766,0.0003010475,0.001218235,0.00007271163,0.001268621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03966487,"threshold_uncertainty_score":0.8440077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02834429814235675,"score_gpt":0.2947415498111932,"score_spread":0.2663972516688364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}