{"id":"W4385667083","doi":"10.1097/01.hs9.0000967892.54405.ff","title":"S245: RUXOLITINIB IN PEDIATRIC PATIENTS WITH TREATMENT-NAIVE OR STEROID-REFRACTORY CHRONIC GRAFT VERSUS HOST DISEASE: PRIMARY FINDINGS FROM THE PHASE II REACH5 STUDY","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Ruxolitinib; Clinical endpoint; Refractory (planetary science); Graft-versus-host disease; Internal medicine; Transplantation; Calcineurin; Hematopoietic stem cell transplantation; Phases of clinical research; Gastroenterology; Clinical trial; Surgery; Bone marrow; Myelofibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001346226,0.0004027239,0.001037071,0.0001800855,0.0002052729,0.000820525,0.0003680736,0.0006123634,0.002850709],"category_scores_gemma":[0.0009831276,0.0001303974,0.0009296453,0.0003640552,0.0002573176,0.0004880355,0.0003606268,0.001032896,0.000541859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005344664,"about_ca_system_score_gemma":0.001091326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005171206,"about_ca_topic_score_gemma":0.002412425,"domain_scores_codex":[0.9994803,0.0002637881,0.00004336204,0.00005867118,0.00009065168,0.00006327064],"domain_scores_gemma":[0.9994308,0.0001064694,0.0001911813,0.00002813818,0.00005459407,0.0001887181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4792444,0.01294165,0.09251303,0.007338692,0.006745199,0.0009609241,0.0006803434,0.003268384,0.04017213,0.0008802954,0.03221493,0.32304],"study_design_scores_gemma":[0.3547017,0.3067498,0.2587574,0.001268756,0.006004503,0.003971818,0.0005781549,0.002287248,0.01396711,0.0004806572,0.05111989,0.0001130149],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658618,0.02270689,0.000297751,0.001074326,0.00009898117,0.0008721224,0.005251487,0.00007625031,0.003760329],"genre_scores_gemma":[0.9812267,0.006826451,0.000842867,0.001226323,0.0002011916,0.0007847513,0.007991176,0.00002128833,0.0008792391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002850709,"threshold_uncertainty_score":0.009536564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02834429814235675,"score_gpt":0.2947415498111932,"score_spread":0.2663972516688364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}