{"id":"W4385667119","doi":"10.1097/01.hs9.0000968768.84940.f7","title":"P465: N-MYRISTOYLATION INHIBITION ABROGATES OXIDATIVE PHOSPHORYLATION TO TARGET ACUTE MYELOID LEUKEMIA STEM CELLS","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"","keywords":"Myristoylation; Myeloid leukemia; Signal transduction; Biology; Cancer research; Stem cell; Phosphorylation; Oxidative phosphorylation; Kinase; Leukemia; Cell biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537274,0.0003949525,0.0002797447,0.0001994208,0.0001722589,0.0002706009,0.0002956196,0.0002846205,0.003276757],"category_scores_gemma":[0.00007725705,0.00009514453,0.0003101856,0.0001909373,0.0002514293,0.0002123967,0.0002243332,0.0009003052,0.0007959923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002414083,"about_ca_system_score_gemma":0.0003102465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003852224,"about_ca_topic_score_gemma":0.0004273083,"domain_scores_codex":[0.9997968,0.00002118115,0.00002819028,0.0000350807,0.00006606607,0.00005268644],"domain_scores_gemma":[0.9999237,0.000007733396,0.00001939365,0.000009970759,0.000007084703,0.00003210216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007574316,0.0003076334,0.000267981,0.0001437427,0.00001923123,0.00009528713,0.00003063281,0.0003002931,0.991028,0.0004218777,0.0004289111,0.006199027],"study_design_scores_gemma":[0.0001099138,0.001319642,0.002161724,0.00001150066,0.00003262113,0.0002646123,0.0000190434,0.0008867119,0.9882724,0.0000674772,0.006849552,0.000004759058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888344,0.002447873,0.002536782,0.0002605708,0.0001478869,0.0001029691,0.0009496023,0.0003101301,0.004409687],"genre_scores_gemma":[0.9940144,0.0011504,0.0009489008,0.00009771514,0.000019014,0.00006284133,0.0009407836,0.00002282984,0.002743146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003276757,"threshold_uncertainty_score":0.01096189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009386436860841752,"score_gpt":0.2357359665776633,"score_spread":0.2263495297168215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}