{"id":"W4385667119","doi":"10.1097/01.hs9.0000968768.84940.f7","title":"P465: N-MYRISTOYLATION INHIBITION ABROGATES OXIDATIVE PHOSPHORYLATION TO TARGET ACUTE MYELOID LEUKEMIA STEM CELLS","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"","keywords":"Myristoylation; Myeloid leukemia; Signal transduction; Biology; Cancer research; Stem cell; Phosphorylation; Oxidative phosphorylation; Kinase; Leukemia; Cell biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001766098,0.0001961081,0.000143159,0.00006137619,0.0001482243,0.00004471756,0.00009965368,0.0001942426,0.0001942865],"category_scores_gemma":[0.00002518502,0.0002026978,0.00008502322,0.0004057268,0.00003381461,0.00002038513,0.00009926794,0.00009532474,0.001001648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009766803,"about_ca_system_score_gemma":0.00008903316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000016922,"about_ca_topic_score_gemma":0.00001732342,"domain_scores_codex":[0.9987479,0.00005831889,0.0002680674,0.0004303299,0.0002238801,0.0002714387],"domain_scores_gemma":[0.9993283,0.00001222323,0.00011663,0.0002837107,0.0001346009,0.0001245183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007254391,0.00001583319,0.0001825453,0.00001631175,0.00003401986,0.000006757917,0.0001324961,0.0007762118,0.9389666,0.00011332,0.05627248,0.003410834],"study_design_scores_gemma":[0.0003540688,0.0001596051,0.0005173041,0.00002680608,0.0000119312,0.000004178221,0.0002409543,0.0004302718,0.9107513,0.0001566818,0.08711695,0.0002298965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896991,0.0002344099,0.005595109,0.0003371558,0.0003386386,0.0005577795,0.00008771682,0.0001498581,0.003000259],"genre_scores_gemma":[0.9818441,0.0001426607,0.002376537,0.0003985461,0.0003004613,0.0001173118,0.001270946,0.00004850869,0.01350088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03084447,"threshold_uncertainty_score":0.9997762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009386436860841752,"score_gpt":0.2357359665776633,"score_spread":0.2263495297168215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}