{"id":"W4385667241","doi":"10.1097/01.hs9.0000970972.77960.03","title":"P1017: REDUCTIONS IN INDOLENT SYSTEMIC MASTOCYTOSIS BIOMARKER BURDEN WITH AVAPRITINIB IN THE REGISTRATIONAL, DOUBLE-BLIND PLACEBO-CONTROLLED PIONEER TRIAL","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; University of Alberta; University of Calgary","funders":"","keywords":"Medicine; Systemic mastocytosis; Tryptase; Placebo; Internal medicine; Gastroenterology; Biomarker; Placebo-controlled study; Randomized controlled trial; Mast cell; Bone marrow; Immunology; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001472157,0.00131913,0.002503024,0.0003050678,0.0004057128,0.001219192,0.0009061892,0.002075356,0.008989905],"category_scores_gemma":[0.001321061,0.000435961,0.001971381,0.0002821279,0.0009582033,0.0009988967,0.0003119926,0.0029564,0.001574541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006901799,"about_ca_system_score_gemma":0.001055303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007271431,"about_ca_topic_score_gemma":0.002561054,"domain_scores_codex":[0.9994931,0.0002379996,0.00002899147,0.00009507043,0.00006788613,0.00007693019],"domain_scores_gemma":[0.9994289,0.0001363022,0.0001529405,0.00004702974,0.00004963443,0.0001850787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9613009,0.004116476,0.0004371016,0.001710672,0.00123174,0.00005781492,0.00005262753,0.0002958508,0.006585953,0.0002208441,0.002275069,0.02171496],"study_design_scores_gemma":[0.9625829,0.03441629,0.001303725,0.00004335888,0.000309097,0.00003581666,0.000009830476,0.0001565982,0.0002847636,0.0000975438,0.0007492646,0.00001068928],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658712,0.01634482,0.0007462702,0.001863175,0.001105063,0.004263596,0.002874274,0.0004184252,0.006513307],"genre_scores_gemma":[0.9757082,0.005688688,0.001583626,0.001966431,0.001012602,0.004051489,0.002844268,0.00004229531,0.007102371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008989905,"threshold_uncertainty_score":0.03007424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04868060214724758,"score_gpt":0.2799370876052603,"score_spread":0.2312564854580128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}