{"id":"W4385667241","doi":"10.1097/01.hs9.0000970972.77960.03","title":"P1017: REDUCTIONS IN INDOLENT SYSTEMIC MASTOCYTOSIS BIOMARKER BURDEN WITH AVAPRITINIB IN THE REGISTRATIONAL, DOUBLE-BLIND PLACEBO-CONTROLLED PIONEER TRIAL","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; University of Alberta; University of Calgary","funders":"","keywords":"Medicine; Systemic mastocytosis; Tryptase; Placebo; Internal medicine; Gastroenterology; Biomarker; Placebo-controlled study; Randomized controlled trial; Mast cell; Bone marrow; Immunology; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007558817,0.0002067369,0.000422559,0.0001801822,0.0001676988,0.00003982951,0.0002368643,0.000243504,0.001159445],"category_scores_gemma":[0.00003962043,0.0001389227,0.00009610903,0.0006079429,0.0001456749,0.00007212738,0.00003657168,0.0003619273,0.0004386962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000691488,"about_ca_system_score_gemma":0.00015083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003079929,"about_ca_topic_score_gemma":0.001056486,"domain_scores_codex":[0.9983485,0.000284145,0.0005381896,0.0003605053,0.0001022944,0.000366351],"domain_scores_gemma":[0.9991532,0.0002453188,0.0001611229,0.0003682735,0.0000527649,0.00001935085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8760981,0.000979932,0.0007455646,0.0002612882,0.0006034032,0.0002193749,0.006554298,0.001439796,0.05399968,0.008610368,0.04888861,0.001599589],"study_design_scores_gemma":[0.9286179,0.0006893491,0.001311455,0.0005315238,0.0001581029,0.0004962235,0.01308056,0.00009829307,0.001042716,0.0001322024,0.05324262,0.0005990585],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803028,0.001470335,0.00001960749,0.002344751,0.0005436932,0.002803328,0.00002221767,0.00007593141,0.01241736],"genre_scores_gemma":[0.9804732,0.00007568968,0.00002268123,0.00003872146,0.000123423,0.001194185,0.0002058547,0.00002055161,0.01784565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05295696,"threshold_uncertainty_score":0.9997537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04868060214724758,"score_gpt":0.2799370876052603,"score_spread":0.2312564854580128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}