{"id":"W4385667297","doi":"10.1097/01.hs9.0000968132.86513.06","title":"S305: PHASE 2 RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, MULTICENTER STUDY OF RECOMBINANT ADAMTS13 IN PATIENTS WITH IMMUNE-MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; Western University","funders":"","keywords":"Medicine; ADAMTS13; Thrombotic thrombocytopenic purpura; Placebo; Internal medicine; Gastroenterology; Clinical endpoint; Adverse effect; Thrombotic microangiopathy; Randomized controlled trial; Platelet; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00215453,0.001971614,0.002612499,0.0004130432,0.0004683198,0.0008525435,0.0008559125,0.002024208,0.009642081],"category_scores_gemma":[0.001481343,0.0007941774,0.001508579,0.0004066438,0.0008502168,0.0009765695,0.0003396776,0.00241695,0.001522266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006169283,"about_ca_system_score_gemma":0.002176397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007061152,"about_ca_topic_score_gemma":0.002229684,"domain_scores_codex":[0.9993519,0.0003527297,0.00004073313,0.0001002219,0.00004986407,0.0001044793],"domain_scores_gemma":[0.999278,0.000158651,0.0001820054,0.00005871684,0.00006604294,0.0002566344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9671157,0.01180592,0.0005940294,0.0005995226,0.0004519206,0.0000407286,0.00005606333,0.0003145202,0.005055482,0.0001018041,0.001304205,0.01256014],"study_design_scores_gemma":[0.9378088,0.06022801,0.0009742153,0.00001695701,0.00009505841,0.0000229256,0.00000881966,0.0001717363,0.0002177173,0.00005505611,0.0003933017,0.000007442292],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693891,0.004017436,0.001334226,0.0008661512,0.0005920409,0.01801971,0.002913455,0.0003193562,0.00254859],"genre_scores_gemma":[0.9619349,0.002456954,0.004034613,0.001786811,0.000560642,0.0222573,0.002478844,0.00004347165,0.004446558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009642081,"threshold_uncertainty_score":0.03225601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02440366224807412,"score_gpt":0.2909944128602566,"score_spread":0.2665907506121825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}