{"id":"W4385667297","doi":"10.1097/01.hs9.0000968132.86513.06","title":"S305: PHASE 2 RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, MULTICENTER STUDY OF RECOMBINANT ADAMTS13 IN PATIENTS WITH IMMUNE-MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; Western University","funders":"","keywords":"Medicine; ADAMTS13; Thrombotic thrombocytopenic purpura; Placebo; Internal medicine; Gastroenterology; Clinical endpoint; Adverse effect; Thrombotic microangiopathy; Randomized controlled trial; Platelet; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0008852269,0.0004562746,0.002196326,0.0002529719,0.0001461714,0.00002648668,0.0004755413,0.0001712796,0.002758079],"category_scores_gemma":[0.0001772001,0.0003244852,0.000260783,0.0006352767,0.0002052504,0.0001898578,0.0002441619,0.0003089392,0.0008091716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009731975,"about_ca_system_score_gemma":0.0001010405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004579512,"about_ca_topic_score_gemma":0.0005707,"domain_scores_codex":[0.9960581,0.000969978,0.001492636,0.0006048239,0.0002009915,0.0006734399],"domain_scores_gemma":[0.9973835,0.0009551169,0.0006468707,0.0007644289,0.0001995542,0.00005049767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9109066,0.009628217,0.07249175,0.0001516049,0.002085735,0.00003379825,0.002116231,0.00009953657,0.0009060774,0.00005474964,0.001302996,0.000222726],"study_design_scores_gemma":[0.9676386,0.00140714,0.02461364,0.0002945119,0.0004477174,0.000001805302,0.004683807,0.0000704804,0.0003808863,0.00001668975,0.0000818635,0.0003628713],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859738,0.0007456191,0.000005668988,0.00005095654,0.0009708833,0.01176251,0.00003890692,0.0001526853,0.000298908],"genre_scores_gemma":[0.9969299,0.00002587972,0.00001069412,0.00001674275,0.00001170522,0.001452307,0.000525785,0.00005763712,0.000969362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05673201,"threshold_uncertainty_score":0.9999688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02440366224807412,"score_gpt":0.2909944128602566,"score_spread":0.2665907506121825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}