{"id":"W4385667605","doi":"10.1097/01.hs9.0000970892.97539.5e","title":"P997: FEDRATINIB IS EFFECTIVE IN RUXOLITINIB-RESISTANT CELLS: CLINICAL AND PRECLINICAL CORRELATIONS","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ruxolitinib; Myelofibrosis; Myeloproliferative neoplasm; Medicine; Kinome; Cancer research; Dasatinib; Internal medicine; Janus kinase 2; Immunology; Oncology; Pharmacology; Bone marrow; Kinase; Biology; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007987353,0.0003244384,0.0006088307,0.0002988706,0.0002099109,0.0009219021,0.0003873692,0.0005676235,0.003965926],"category_scores_gemma":[0.0005575859,0.000107001,0.0003100454,0.0003968112,0.0002950814,0.0004117254,0.0002246152,0.00104987,0.001050639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004660382,"about_ca_system_score_gemma":0.0004470687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003090126,"about_ca_topic_score_gemma":0.0008284686,"domain_scores_codex":[0.9997247,0.00007138988,0.00003165816,0.00003263969,0.00008493351,0.00005454564],"domain_scores_gemma":[0.9996375,0.0000762542,0.0001020185,0.00003038498,0.00007941352,0.00007455274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01430922,0.006434164,0.02294229,0.001572434,0.0003452683,0.001172331,0.0002436296,0.001890353,0.6911092,0.001457465,0.0156581,0.2428655],"study_design_scores_gemma":[0.008427734,0.143283,0.2354297,0.0005214778,0.0008653698,0.01025362,0.0004908507,0.009639393,0.4950656,0.001533154,0.09439103,0.00009909343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968015,0.01492425,0.0008983227,0.001567835,0.0001500622,0.000416567,0.002662366,0.0002020959,0.01116357],"genre_scores_gemma":[0.9863495,0.004737762,0.0008527465,0.0004276352,0.00009721786,0.0001633134,0.004621185,0.00002787661,0.002722756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003965926,"threshold_uncertainty_score":0.01326728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05031368172403101,"score_gpt":0.3819137140479928,"score_spread":0.3316000323239618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}