{"id":"W4385667605","doi":"10.1097/01.hs9.0000970892.97539.5e","title":"P997: FEDRATINIB IS EFFECTIVE IN RUXOLITINIB-RESISTANT CELLS: CLINICAL AND PRECLINICAL CORRELATIONS","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ruxolitinib; Myelofibrosis; Myeloproliferative neoplasm; Medicine; Kinome; Cancer research; Dasatinib; Internal medicine; Janus kinase 2; Immunology; Oncology; Pharmacology; Bone marrow; Kinase; Biology; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005209483,0.0002201413,0.00059552,0.00006443173,0.0001059955,0.00002821647,0.00004771827,0.0002270173,0.0007904048],"category_scores_gemma":[0.0004726191,0.0001759981,0.0001596752,0.0003205487,0.0001647271,0.00005994138,0.00007038045,0.0003920812,0.0007539097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004776475,"about_ca_system_score_gemma":0.0001307787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004958753,"about_ca_topic_score_gemma":0.0001983007,"domain_scores_codex":[0.9980003,0.0002054654,0.0006681604,0.0005549612,0.0002429706,0.0003281182],"domain_scores_gemma":[0.9973112,0.001946319,0.0001006384,0.0003008965,0.00008322467,0.0002576835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004885822,0.0008700236,0.9610857,0.0001348987,0.0001743824,0.0003362235,0.0008193752,0.000006166289,0.0001742876,0.002016732,0.02122121,0.01267238],"study_design_scores_gemma":[0.005209832,0.00114833,0.9759866,0.0003518993,0.0001356646,0.00001781481,0.0004680867,0.0009559827,0.001399177,0.0006821728,0.01344121,0.0002032575],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850221,0.0004748045,0.0000153061,0.002843815,0.0002687709,0.001325161,0.0000582527,0.0001181603,0.009873668],"genre_scores_gemma":[0.9943094,0.0005355384,0.0008003032,0.0007946595,0.0002110085,0.0003664155,0.00005059229,0.00003290188,0.002899203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01490084,"threshold_uncertainty_score":0.9690235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05031368172403101,"score_gpt":0.3819137140479928,"score_spread":0.3316000323239618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}