{"id":"W4385684657","doi":"10.1016/j.celrep.2023.112937","title":"RETRACTED: ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":19,"is_retracted":true,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Biology; Transcription factor; Cancer research; Receptor tyrosine kinase; Signal transduction; MAPK/ERK pathway; Prostate cancer; Lineage (genetic); Cell biology; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0007962961,0.0005472787,0.0005374579,0.0007648483,0.001082217,0.001371824,0.001821643,0.002420075,0.03604689],"category_scores_gemma":[0.002836644,0.0002247489,0.0005021172,0.0006751422,0.0009798519,0.001293263,0.0008819414,0.00354409,0.01516182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001217939,"about_ca_system_score_gemma":0.001197245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001803918,"about_ca_topic_score_gemma":0.002971302,"domain_scores_codex":[0.9993685,0.00006266525,0.00007196794,0.0001013862,0.0002752374,0.0001203545],"domain_scores_gemma":[0.9981262,0.0003472084,0.000194353,0.0001767874,0.0007349385,0.0004205423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000431941,0.00006693927,0.00143981,0.0007681149,0.0000384302,0.002381566,0.0001439479,0.0001999587,0.01641397,0.003623842,0.8666983,0.1077933],"study_design_scores_gemma":[0.00004262533,0.0001114058,0.00399314,0.0001271398,0.00003272614,0.003219082,0.000251587,0.0004893373,0.01533696,0.002017597,0.9743462,0.00003224194],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"editorial","genre_gemma":"empirical","genre_scores_codex":[0.04268397,0.04294389,0.01063599,0.3993986,0.4379563,0.0002658459,0.005533335,0.004422022,0.05616013],"genre_scores_gemma":[0.2107096,0.03956458,0.006950401,0.1167301,0.09971711,0.000194712,0.006656559,0.0009304297,0.5185464],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9975799,"threshold_uncertainty_score":0.1205888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02768715438126252,"score_gpt":0.3091537289409558,"score_spread":0.2814665745596933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}