{"id":"W4385684814","doi":"10.1016/j.celrep.2023.112936","title":"CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Prostate Cancer Fight Foundation; McGill University; Institut de Recherche Clinique De Montréal; Canadian Institutes of Health Research; McGill University Health Centre; Mitacs; Prostate Cancer Foundation","keywords":"Intravasation; Cancer research; Metastasis; Transforming growth factor; Epithelial–mesenchymal transition; RHOA; Breast cancer; Signal transduction; Signal transducing adaptor protein; Ezrin; CDC42; Focal adhesion; Biology; Cancer; Medicine; Cell biology; Internal medicine; Cell; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000554966,0.0002336341,0.000126601,0.000288768,0.0002346402,0.0003053801,0.0001311272,0.000204318,0.001004696],"category_scores_gemma":[0.00005761692,0.00006173102,0.0001192966,0.0001939559,0.000174903,0.0001149936,0.0002630717,0.0003065685,0.0002367452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521389,"about_ca_system_score_gemma":0.0001390387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005160369,"about_ca_topic_score_gemma":0.000470348,"domain_scores_codex":[0.999948,0.000006339573,0.000002208616,0.00001073833,0.00001949805,0.00001304892],"domain_scores_gemma":[0.9999552,0.000004571894,0.0000163212,0.000002095587,0.00000484819,0.00001696816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009071965,0.00002317402,0.001071015,0.0000792514,0.000008788553,0.0002577296,0.00001733857,0.00008270303,0.9924138,0.0003807922,0.0002246432,0.005350133],"study_design_scores_gemma":[0.00002318246,0.0003567162,0.03594451,0.00001700281,0.00004586233,0.004569782,0.0001142519,0.001624983,0.9270387,0.0003002874,0.0299539,0.00001085124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773306,0.01169777,0.004525765,0.000529169,0.00006919387,0.00002991753,0.0005752274,0.0001470015,0.005095273],"genre_scores_gemma":[0.9930148,0.00293997,0.001220471,0.00009054703,0.00001904344,0.00001634726,0.0005338977,0.000008982032,0.0021559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004696,"threshold_uncertainty_score":0.003361046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01070191364933719,"score_gpt":0.2413848827372565,"score_spread":0.2306829690879193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}