{"id":"W4385684825","doi":"10.1080/22221751.2023.2246594","title":"A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants","year":2023,"lang":"en","type":"article","venue":"Emerging Microbes & Infections","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; Université de Sherbrooke; Simon Fraser University; University of British Columbia","funders":"National Institute of General Medical Sciences; Office of Science; National Cancer Institute; Faculty of Medicine, University of British Columbia; National Institutes of Health; Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Ural Branch, Russian Academy of Sciences; Canadian Institutes of Health Research; Mitacs; Genome British Columbia; Argonne National Laboratory; U.S. Department of Energy","keywords":"Chemistry; Protease; Active site; Biological activity; Mechanism of action; Virology; Enzyme; Biochemistry; Stereochemistry; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440402,0.0004803771,0.0002967344,0.0002158512,0.0001748107,0.0003277564,0.0003819342,0.0003639521,0.001022451],"category_scores_gemma":[0.00008256178,0.0001076801,0.0002679939,0.0001284255,0.0001749539,0.0001980123,0.0001610057,0.0005208006,0.0002881934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000435267,"about_ca_system_score_gemma":0.0003534531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009986773,"about_ca_topic_score_gemma":0.002217045,"domain_scores_codex":[0.9998819,0.00001460003,0.000007976615,0.00003086749,0.00003715973,0.00002746805],"domain_scores_gemma":[0.999957,0.000003754033,0.000008757696,0.000003989118,0.000007035651,0.00001951515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004775872,0.0003033035,0.0006485626,0.0001545758,0.00003383202,0.0001592093,0.00003515003,0.0008923354,0.9691048,0.0008573678,0.0008277764,0.02650545],"study_design_scores_gemma":[0.0008856952,0.006884667,0.008009095,0.00003658843,0.00007856263,0.002169392,0.00003071526,0.005528644,0.9287785,0.000188338,0.04735906,0.00005073691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648743,0.0135869,0.01165204,0.0002278537,0.0001134573,0.0004099266,0.001134393,0.000265694,0.007735551],"genre_scores_gemma":[0.980072,0.00302161,0.01001396,0.0003100806,0.00003025127,0.0001932028,0.001732935,0.00001528124,0.004610564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022451,"threshold_uncertainty_score":0.003420472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984990527834414,"score_gpt":0.2970492610660888,"score_spread":0.2771993557877447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}