{"id":"W4385686382","doi":"10.4049/jimmunol.210.supp.78.04","title":"Type I Interferon-Dependent and -Independent TRIF Signaling are Required for Autoantibody Generation in an Induced Model of Systemic Lupus Erythematosus","year":2023,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont; McGill University Health Centre","funders":"","keywords":"TRIF; Autoantibody; Immunology; Lipopolysaccharide; TLR3; Interferon; TLR7; Toll-like receptor; Biology; Antibody; Immune system; Innate immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003257674,0.000696769,0.0005006273,0.0004204077,0.0002314396,0.0004027149,0.0002972576,0.0006940918,0.001581242],"category_scores_gemma":[0.0002420504,0.0002289066,0.0005001387,0.0001635982,0.0003595522,0.0003364835,0.0002389906,0.001501658,0.0007693861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003668224,"about_ca_system_score_gemma":0.0002483212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001859759,"about_ca_topic_score_gemma":0.0002213967,"domain_scores_codex":[0.9994259,0.0001300849,0.00008364781,0.00009487239,0.0001167487,0.0001487848],"domain_scores_gemma":[0.9995303,0.00005013277,0.0001600575,0.0000579304,0.0000439973,0.0001576334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005188456,0.0001180269,0.0002170627,0.00006189289,0.000005640463,0.0001147372,0.00001986704,0.00004804779,0.9983004,0.00007682623,0.00004823276,0.0004704889],"study_design_scores_gemma":[0.0001750914,0.001781698,0.01107088,0.0000486066,0.00004778271,0.001310523,0.0001382774,0.002259689,0.9800732,0.0001832336,0.002894884,0.00001613547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934239,0.0008884884,0.002862871,0.0001713832,0.0000709394,0.0001094121,0.001023897,0.0001320245,0.001317161],"genre_scores_gemma":[0.9932554,0.0004368927,0.002631065,0.0001611773,0.00002472672,0.0002585553,0.001061342,0.00003710858,0.002133826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001581242,"threshold_uncertainty_score":0.005289793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09018623086467949,"score_gpt":0.3418355949938792,"score_spread":0.2516493641291997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}