{"id":"W4385687758","doi":"10.4049/jimmunol.210.supp.229.21","title":"Analysis of novel RAC2 variants associated with neutrophil dysfunction, lymphopenia, and primary immunodeficiency","year":2023,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval","funders":"","keywords":"Immunodeficiency; Primary immunodeficiency; Biology; Phenotype; Severe combined immunodeficiency; Immunology; Mutation; Common variable immunodeficiency; Hypogammaglobulinemia; Genetics; Gene; Immune system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656171,0.0005025637,0.0002141588,0.0006631997,0.0002031798,0.0002476986,0.0001763153,0.0004301573,0.001135735],"category_scores_gemma":[0.0004117217,0.0001161278,0.0002613926,0.0002714854,0.0002338806,0.00008725769,0.0002430368,0.0002347693,0.0002112344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001437312,"about_ca_system_score_gemma":0.00009487807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006001639,"about_ca_topic_score_gemma":0.0004317805,"domain_scores_codex":[0.9998125,0.0000305742,0.00002545888,0.0000541957,0.00004096407,0.00003626281],"domain_scores_gemma":[0.9997905,0.00005722055,0.00005712731,0.00001352473,0.00002838732,0.00005334585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001057196,0.0001693611,0.1339348,0.00008131749,0.00006939638,0.03741579,0.0003581631,0.000305694,0.8208663,0.0002906001,0.0002392647,0.005212252],"study_design_scores_gemma":[0.000075146,0.00151532,0.6350908,0.00005300186,0.0001575946,0.1902443,0.0004086137,0.004419276,0.1638929,0.000306274,0.00379822,0.00003863019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986339,0.0001358166,0.0006215672,0.00002492385,0.000005855302,0.00001843888,0.0002453126,0.00001459608,0.0002994717],"genre_scores_gemma":[0.9990331,0.0000468773,0.0004564975,0.00002022507,0.000004611747,0.000006516432,0.0002257683,0.000006516992,0.0001998993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135735,"threshold_uncertainty_score":0.003799438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456929445945674,"score_gpt":0.2183870594668092,"score_spread":0.2038177650073525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}