{"id":"W4385690595","doi":"10.1038/s41467-023-40494-5","title":"Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacterium","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Fondo para la Investigación Científica y Tecnológica; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Case Western Reserve University; Government of Canada; Génome Québec; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; U.S. Department of Veterans Affairs","keywords":"Antibiotics; Bacteria; Microbiology; Antibiotic resistance; Multiple drug resistance; Profiling (computer programming); Cell envelope; Biology; Computational biology; Genetics; Gene; Computer science; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001251666,0.000212973,0.0002663877,0.000252891,0.0001636526,0.0004412529,0.0001509974,0.0003260106,0.0004735924],"category_scores_gemma":[0.000230192,0.0001356254,0.0001860062,0.0002540491,0.0001120029,0.0001920241,0.0002912948,0.0003654489,0.0002589493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001461377,"about_ca_system_score_gemma":0.0001304481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007573377,"about_ca_topic_score_gemma":0.001184181,"domain_scores_codex":[0.9998411,0.00001857775,0.0000107496,0.00003676105,0.00006227312,0.00003065022],"domain_scores_gemma":[0.9998469,0.00003702288,0.00004559246,0.00001839307,0.00002608022,0.00002592598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002755983,0.00001832821,0.002108606,0.00001476997,0.000004072354,0.00002211544,0.00001820098,0.00007793371,0.9964121,0.00001175527,0.00001701161,0.001267706],"study_design_scores_gemma":[0.000007282723,0.0006351086,0.1545784,0.00001540004,0.00005795066,0.0009624276,0.0003926856,0.004260099,0.836271,0.0001468914,0.0026526,0.000020142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959919,0.0003189965,0.002498157,0.00006152,0.000003507613,0.00001046291,0.0006540665,0.00007093866,0.0003905029],"genre_scores_gemma":[0.9929827,0.0005214456,0.004389396,0.00008938313,0.000003121522,0.00001696403,0.001110377,0.00002638482,0.0008603277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007573377,"threshold_uncertainty_score":0.001584291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902228788556709,"score_gpt":0.3126574470378047,"score_spread":0.2936351591522376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}