{"id":"W4385693897","doi":"10.1126/sciadv.adf4082","title":"FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Hôpital Maisonneuve-Rosemont; Université de Montréal; Université Laval; Hôtel-Dieu de Québec; McGill University; Jewish General Hospital","funders":"","keywords":"RAD51; DNA repair; DNA; DNA damage; Genome instability; Cell biology; Biology; Homologous recombination; Molecular biology; CRISPR; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002086182,0.000331989,0.0002795631,0.0001969864,0.0001653312,0.0003335814,0.0003274594,0.0004673919,0.001091774],"category_scores_gemma":[0.0002145992,0.000194267,0.000275366,0.00008967848,0.0002076965,0.0002051508,0.0002896614,0.0004128212,0.0007329307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005215695,"about_ca_system_score_gemma":0.0001828261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003540336,"about_ca_topic_score_gemma":0.000697323,"domain_scores_codex":[0.9997975,0.00003387104,0.00001637962,0.0000611873,0.00004237662,0.00004872261],"domain_scores_gemma":[0.9998166,0.0000270897,0.00007709833,0.00002578004,0.000009897295,0.00004352962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003749217,0.00001053542,0.000144402,0.00001654578,0.000001789535,0.00003938149,0.000004490849,0.00004902027,0.9991709,0.00004334779,0.00002732198,0.0004548666],"study_design_scores_gemma":[0.000006788376,0.00006388962,0.004832149,0.000004160223,0.000005347627,0.0002494391,0.00001133466,0.001208706,0.9919477,0.00001922828,0.001646881,0.000004421154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922069,0.001298193,0.004245135,0.0001312943,0.0000246646,0.00001627605,0.0002102734,0.0002726471,0.001594659],"genre_scores_gemma":[0.9944876,0.000255954,0.002702735,0.00006161218,0.000006044542,0.00001286824,0.0003526699,0.00004855887,0.002071894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001091774,"threshold_uncertainty_score":0.003784299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005252021046140698,"score_gpt":0.2976160581235712,"score_spread":0.2923640370774305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}