{"id":"W4385693995","doi":"10.1021/acschembio.3c00280","title":"SETDB1 Triple Tudor Domain Ligand, ( <i>R</i> , <i>R</i> )-59, Promotes Methylation of Akt1 in Cells","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Genentech; Ontario Genomics; National Institutes of Health; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; McGill University; Pharmaceutical Research and Manufacturers of America Foundation; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Methylation; Methyltransferase; Biology; Phosphorylation; In vitro; Activator (genetics); Cell biology; Receptor; Molecular biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007225166,0.0002073868,0.0001455142,0.00008273003,0.0001240242,0.0001493481,0.0001462386,0.0001698434,0.002670544],"category_scores_gemma":[0.00006709173,0.00009237831,0.0002000568,0.00006398882,0.0001107222,0.0001047465,0.0001921951,0.0003344083,0.0005276149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000230548,"about_ca_system_score_gemma":0.0001367874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003275746,"about_ca_topic_score_gemma":0.0006753426,"domain_scores_codex":[0.999921,0.00001024156,0.000005457838,0.00001971396,0.00002429339,0.00001924418],"domain_scores_gemma":[0.999966,0.000004897478,0.00001008775,0.000004115011,0.00000303406,0.00001188799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005668243,0.00001358618,0.00006691428,0.00001906577,0.000002861508,0.00002000764,0.000003536444,0.00003250916,0.9989673,0.00006549824,0.00005604339,0.0006959782],"study_design_scores_gemma":[0.000008933814,0.000125353,0.00101275,0.000002051697,0.000004444906,0.0001230067,0.000007155337,0.0002473038,0.9967975,0.00001966571,0.001649949,0.000002058427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894522,0.002628153,0.003215617,0.0001834252,0.00006805627,0.00002414297,0.0004314684,0.0001117917,0.003885059],"genre_scores_gemma":[0.9942028,0.0008687482,0.001509532,0.00005639493,0.00001074399,0.00001915242,0.0005313818,0.0000112806,0.002789875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002670544,"threshold_uncertainty_score":0.008933902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008379697415606187,"score_gpt":0.2524222970679676,"score_spread":0.2440425996523615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}