{"id":"W4385694006","doi":"10.1126/sciadv.adf7119","title":"TNIK is a conserved regulator of glucose and lipid metabolism in obesity","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Helsinki Institute of Life Science, Helsingin Yliopisto; Bispebjerg Hospital; Diabetestutkimussäätiö; Novo Nordisk Fonden; Orionin Tutkimussäätiö; Sigrid Juséliuksen Säätiö; Hospital for Sick Children; Maud Kuistilan Muistosäätiö; Novo Nordisk; H. Lundbeck A/S; Jane ja Aatos Erkon Säätiö; Sickkids Research Institute; Biocenter Finland; Lundbeckfonden; Deutsche Forschungsgemeinschaft; European Commission","keywords":"Endocrinology; Lipid metabolism; Internal medicine; Lipogenesis; Insulin resistance; Glucose homeostasis; Steatosis; Biology; Carbohydrate metabolism; Type 2 diabetes; Adipose tissue; Insulin; Diabetes mellitus; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473118,0.0005354793,0.0002886871,0.0004542536,0.0002777822,0.000581926,0.0002753342,0.0003277542,0.00217851],"category_scores_gemma":[0.0002318511,0.0001126891,0.000287278,0.0004797207,0.0002435566,0.0002057122,0.0003529749,0.0004539369,0.001057033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003889984,"about_ca_system_score_gemma":0.0003067509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001795829,"about_ca_topic_score_gemma":0.001475056,"domain_scores_codex":[0.9998754,0.00001247972,0.00001121343,0.00004074016,0.00004143271,0.00001863549],"domain_scores_gemma":[0.9998299,0.00001701132,0.00007787914,0.00001223141,0.00001890762,0.00004410839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002162865,0.00007988926,0.02519144,0.0006475528,0.0001426747,0.001903734,0.0001949719,0.001140755,0.9197778,0.003217694,0.004217647,0.04132291],"study_design_scores_gemma":[0.0003862056,0.0008098618,0.5153123,0.0003928408,0.0004272689,0.01452844,0.0004497276,0.008218942,0.3183384,0.005200726,0.1357482,0.0001870754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9379978,0.02152829,0.01506071,0.0009891259,0.0003392121,0.00008763492,0.01233082,0.001085272,0.01058111],"genre_scores_gemma":[0.9738508,0.005391587,0.004204642,0.0002870173,0.00007014985,0.00003852438,0.01018127,0.00008798259,0.00588811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00217851,"threshold_uncertainty_score":0.00728786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009769857422517075,"score_gpt":0.2705152392077687,"score_spread":0.2607453817852516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}