{"id":"W4385694243","doi":"10.1016/j.jacbts.2023.05.008","title":"TAK1 Activation by NLRP3 Deficiency Confers Cardioprotection Against Pressure Overload-Induced Cardiomyocyte Pyroptosis and Hypertrophy","year":2023,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University Health Network","funders":"Zhongshan Hospital; Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China","keywords":"Pyroptosis; Cardioprotection; Pressure overload; Cardiac hypertrophy; Muscle hypertrophy; Inflammation; Medicine; Cardiology; Internal medicine; Volume overload; Myocardial infarction; Cell biology; Inflammasome; Heart failure; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002225795,0.0004177247,0.0003732001,0.0002942179,0.0001497977,0.0003243162,0.0002053166,0.0003355446,0.002304342],"category_scores_gemma":[0.0001353572,0.0001381398,0.0003787435,0.0001266552,0.0003660697,0.0003207726,0.0002954215,0.00090591,0.0003682925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849019,"about_ca_system_score_gemma":0.0002180559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001505762,"about_ca_topic_score_gemma":0.0002603681,"domain_scores_codex":[0.9998019,0.00003734098,0.00003180827,0.00003696674,0.00004231933,0.00004967773],"domain_scores_gemma":[0.9998153,0.00002449148,0.00006077576,0.00002530577,0.00001000274,0.0000641688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000204213,0.00002311401,0.00007505356,0.00002952969,0.000004236058,0.00004998434,0.00001147903,0.00002725253,0.9987975,0.00007487241,0.00001824304,0.0006844884],"study_design_scores_gemma":[0.00006672496,0.001051838,0.006252284,0.00001630492,0.00002518938,0.0008183678,0.00007302692,0.0006844426,0.9892687,0.0002202576,0.001511523,0.00001133392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990886,0.001576618,0.004971591,0.0002224122,0.00008050399,0.00002739282,0.000456875,0.0001998219,0.001578669],"genre_scores_gemma":[0.9961119,0.0005576693,0.001913156,0.00006327211,0.00001798918,0.00002704085,0.0003042116,0.00002365463,0.0009811993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002304342,"threshold_uncertainty_score":0.007708788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007948166770614384,"score_gpt":0.2303566905063656,"score_spread":0.2224085237357512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}