{"id":"W4385694243","doi":"10.1016/j.jacbts.2023.05.008","title":"TAK1 Activation by NLRP3 Deficiency Confers Cardioprotection Against Pressure Overload-Induced Cardiomyocyte Pyroptosis and Hypertrophy","year":2023,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University Health Network","funders":"Zhongshan Hospital; Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China","keywords":"Pyroptosis; Cardioprotection; Pressure overload; Cardiac hypertrophy; Muscle hypertrophy; Inflammation; Medicine; Cardiology; Internal medicine; Volume overload; Myocardial infarction; Cell biology; Inflammasome; Heart failure; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003162775,0.0001363364,0.0001113914,0.0001338435,0.0003720674,0.0000685068,0.000172146,0.00008947431,0.000006263826],"category_scores_gemma":[0.00007029435,0.0001353955,0.00006528963,0.0006960383,0.0001325088,0.00004273238,0.00004259057,0.00007718964,0.0000137666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001541679,"about_ca_system_score_gemma":0.0001479643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006541387,"about_ca_topic_score_gemma":0.000004108557,"domain_scores_codex":[0.9986677,0.00003022239,0.0001544395,0.0004713819,0.0003836188,0.0002926428],"domain_scores_gemma":[0.9995402,0.0000111263,0.00004158532,0.0001955063,0.0001272027,0.00008437937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004515584,0.000009973487,0.0008970947,0.000008727066,0.00001539412,2.219678e-7,0.0001481388,0.001807213,0.9815161,0.00006794627,0.0003351427,0.01514894],"study_design_scores_gemma":[0.0007160258,0.0002260769,0.06781476,0.00001707992,0.00002529276,0.000004032283,0.000219118,0.001218494,0.8838615,0.00007162867,0.04543115,0.0003948059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944179,0.0001633731,0.002147207,0.0007963961,0.0001405335,0.0003508891,0.00003090874,0.00003465018,0.001918141],"genre_scores_gemma":[0.9992408,0.00005509718,0.0001155237,0.0002257348,0.00006448614,0.00005202886,0.00007844206,0.0000120199,0.0001558383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09765451,"threshold_uncertainty_score":0.5521269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007948166770614384,"score_gpt":0.2303566905063656,"score_spread":0.2224085237357512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}