{"id":"W4385694287","doi":"10.1016/j.celrep.2023.112942","title":"Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Walter Reed Army Institute of Research; Biological and Environmental Research; Defense Health Agency; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Basic Energy Sciences; Office of Science; National Institutes of Health; National Research Council Canada; University of Chicago; Henry M. Jackson Foundation; Brookhaven National Laboratory; Argonne National Laboratory; U.S. Department of Energy; U.S. Department of Defense","keywords":"Epitope; Virology; Zika virus; Monoclonal antibody; Antibody; Biology; Antigenicity; Antigen; Glycoprotein; Epitope mapping; Virus; Immunology; Molecular biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000336866,0.0002053235,0.0003842221,0.0001359039,0.0001369139,0.00005917954,0.00007201633,0.0000782249,0.0004777142],"category_scores_gemma":[0.0001056416,0.0001754461,0.0002200093,0.0002762454,0.00005324358,0.00008549947,0.0000941802,0.0001737148,0.0002418154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003143098,"about_ca_system_score_gemma":0.00007569364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004322558,"about_ca_topic_score_gemma":0.000001798202,"domain_scores_codex":[0.9982069,0.00003085227,0.0005438327,0.0004971077,0.0002662804,0.0004550073],"domain_scores_gemma":[0.9989537,0.00005508705,0.0001958915,0.0004794504,0.0001074019,0.00020846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001769566,0.0003111995,0.2900403,0.0006360014,0.0002065015,0.02334687,0.001465484,0.00007154843,0.2869893,0.0001823429,0.3500062,0.04656735],"study_design_scores_gemma":[0.0007272747,0.00011355,0.1216859,0.0002935583,0.0001827956,0.0002589151,0.00106504,0.0002070701,0.04231611,0.0002081649,0.8324926,0.0004489508],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731163,0.005966076,0.0001032539,0.0008610183,0.001330842,0.0003901396,0.000003514749,0.0004133557,0.01781545],"genre_scores_gemma":[0.988659,0.000752344,0.0002087434,0.0003347736,0.0005474872,0.00002939297,0.0001091974,0.0000487814,0.009310313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4824865,"threshold_uncertainty_score":0.7154485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02061979439801349,"score_gpt":0.2706605884979528,"score_spread":0.2500407940999393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}