{"id":"W4385697716","doi":"10.1097/01.hs9.0000976796.54495.8a","title":"PB2524: TRIAL IN PROGRESS: THE HIBISCUS-KIDS STUDY, A SINGLE-ARM, OPEN-LABEL, PHASE 1/2 STUDY TO EVALUATE THE PHARMACOKINETICS AND SAFETY OF ETAVOPIVAT IN PEDIATRIC PATIENTS WITH SICKLE CELL DISEASE","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tolerability; Anemia; Sickle cell anemia; Hemolytic anemia; Hemolysis; Adverse effect; Pharmacokinetics; Vaso-occlusive crisis; Disease; Internal medicine; Pharmacology; Gastroenterology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001138717,0.001324271,0.002019546,0.0003009969,0.0002903316,0.001275056,0.0007705964,0.001382444,0.007108652],"category_scores_gemma":[0.0007653951,0.0004322162,0.001494246,0.0002963592,0.0006906004,0.001084141,0.0002579294,0.003434856,0.001256623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00057146,"about_ca_system_score_gemma":0.001019074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006508218,"about_ca_topic_score_gemma":0.001932705,"domain_scores_codex":[0.9997463,0.000118498,0.00001268094,0.00004799058,0.00002617727,0.00004834128],"domain_scores_gemma":[0.9996198,0.00006490656,0.00009408737,0.00002540542,0.00002516253,0.0001705593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7761477,0.01986381,0.00408429,0.003365782,0.00302357,0.0005306617,0.0003088892,0.002268387,0.01713191,0.001383582,0.01645489,0.1554364],"study_design_scores_gemma":[0.816987,0.1633237,0.006522765,0.0002213214,0.0006688609,0.0005576627,0.00009486546,0.001188678,0.001436106,0.0005007788,0.00845063,0.00004757586],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9389719,0.03898489,0.001784121,0.00264708,0.0006280818,0.003519113,0.005728068,0.0005161774,0.007220486],"genre_scores_gemma":[0.954208,0.01661624,0.004274363,0.003728736,0.0004229805,0.004393468,0.005404826,0.0001218168,0.01082973],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.007108652,"threshold_uncertainty_score":0.02378082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03078124962771077,"score_gpt":0.3320431455114856,"score_spread":0.3012618958837748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}