{"id":"W4385697716","doi":"10.1097/01.hs9.0000976796.54495.8a","title":"PB2524: TRIAL IN PROGRESS: THE HIBISCUS-KIDS STUDY, A SINGLE-ARM, OPEN-LABEL, PHASE 1/2 STUDY TO EVALUATE THE PHARMACOKINETICS AND SAFETY OF ETAVOPIVAT IN PEDIATRIC PATIENTS WITH SICKLE CELL DISEASE","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tolerability; Anemia; Sickle cell anemia; Hemolytic anemia; Hemolysis; Adverse effect; Pharmacokinetics; Vaso-occlusive crisis; Disease; Internal medicine; Pharmacology; Gastroenterology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00094668,0.0002702236,0.0004659888,0.000109554,0.0001231625,0.00004801746,0.0003163939,0.00005002695,0.00006412152],"category_scores_gemma":[0.0001682129,0.000134817,0.00003302264,0.001680363,0.0001064913,0.00007710219,0.0003852261,0.0003608993,0.00001353553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005508728,"about_ca_system_score_gemma":0.0002023216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006709152,"about_ca_topic_score_gemma":0.0001413363,"domain_scores_codex":[0.9974756,0.0004010984,0.0006080614,0.000449692,0.0006714556,0.0003940469],"domain_scores_gemma":[0.9988649,0.0001868403,0.0001260038,0.0004947009,0.0001269543,0.0002005846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.0983588,0.08721292,0.7781302,0.0003003438,0.000155595,0.0002867234,0.01731551,0.0003122361,0.00003249486,0.000005415737,0.001990794,0.01589896],"study_design_scores_gemma":[0.6888384,0.03795209,0.2363112,0.0002976208,0.001643254,0.000001594357,0.03221796,0.001091133,0.00005052979,0.00003302243,0.001024615,0.0005385666],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845065,0.0008102651,0.000001049888,0.001370919,0.0001401859,0.01281453,0.00001970021,0.00003256499,0.0003042518],"genre_scores_gemma":[0.9989613,0.0001668708,0.00002444446,0.0001528789,0.00006326588,0.000336481,0.00001731826,0.00004442225,0.0002330345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5904796,"threshold_uncertainty_score":0.5497677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03078124962771077,"score_gpt":0.3320431455114856,"score_spread":0.3012618958837748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}