{"id":"W4385697985","doi":"10.1097/01.hs9.0000974984.02232.24","title":"PB2045: USE OF ANAKINRA IN THE TREATMENT OF ADULT HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS: A SYSTEMATIC REVIEW","year":2023,"lang":"en","type":"review","venue":"HemaSphere","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McMaster University","funders":"","keywords":"Anakinra; Hemophagocytic lymphohistiocytosis; Medicine; Macrophage activation syndrome; Pediatrics; Retrospective cohort study; Internal medicine; Cytokine storm; Primary immunodeficiency; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004566598,0.0004699595,0.005987371,0.0001885422,0.0000332263,0.00001278319,0.0003389248,0.0002488224,0.0001428589],"category_scores_gemma":[0.0008228599,0.0002508569,0.001163239,0.001289197,0.0001205757,0.00005646756,0.00004132337,0.0002045845,0.0001892938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003915415,"about_ca_system_score_gemma":0.0009699541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000196591,"about_ca_topic_score_gemma":0.00003844807,"domain_scores_codex":[0.995681,0.0005830439,0.002344273,0.000351932,0.0007028413,0.0003368721],"domain_scores_gemma":[0.9966515,0.0006189225,0.0009921537,0.001456426,0.0002176378,0.000063354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0000132523,0.000389721,0.000007868367,0.9551178,0.0005243915,0.0001373501,0.0002109159,2.120722e-7,2.157362e-7,0.0001047719,0.0006950042,0.04279851],"study_design_scores_gemma":[0.0006520996,0.0004520851,0.000005448927,0.8656942,0.004813678,0.0001197378,0.0002789296,0.00001562639,0.000002600319,0.00000374916,0.127788,0.0001738898],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000547065,0.9922697,0.000001181448,0.00004263101,0.00003509229,0.007188535,0.00004123262,0.00002976763,0.0003371586],"genre_scores_gemma":[0.00002451279,0.9957717,0.0000329809,0.00008160676,0.00002404909,0.001725058,0.00009663853,0.00007817079,0.0021653],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.127093,"threshold_uncertainty_score":0.9999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1231056789853798,"score_gpt":0.3872002908171469,"score_spread":0.2640946118317671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}