{"id":"W4385701286","doi":"10.1186/s13058-023-01691-8","title":"A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry","year":2023,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; Queen's University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University Health Network; University of Toronto","funders":"Medical Research and Materiel Command; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; National Institute of Environmental Health Sciences; U.S. Army; National Institutes of Health; Hellenic Health Foundation; Xunta de Galicia; Rheinische Friedrich-Wilhelms-Universität Bonn; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Centers for Disease Control and Prevention; Institut National Du Cancer; National Center for Chronic Disease Prevention and Health Promotion; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Kuopion Yliopistollinen Sairaala; Government of Canada; University of Cambridge; Ministerio de Sanidad, Servicios Sociales e Igualdad; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; University of Crete; Institut National de la Santé et de la Recherche Médicale; Cancer Australia; Agence Nationale de la Recherche; National Institute on Aging; Robert Bosch Stiftung; Agency for Science, Technology and Research; Cancer Council South Australia; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; Cancer Council Western Australia; European Commission; Eberhard Karls Universität Tübingen; Wellcome Trust; Memorial Sloan-Kettering Cancer Center; Fondation du cancer du sein du Québec; National Breast Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Swedish Cancer Foundation; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Genome Canada; Sundhed og Sygdom, Det Frie Forskningsråd; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; National Institute for Health and Care Research; Harvard T.H. Chan School of Public Health; Division of Cancer Prevention, National Cancer Institute; Cancer Council Victoria; California Department of Public Health; Brigham and Women's Hospital; Breast Cancer Research Foundation; Cancer Research UK; Stavros Niarchos Foundation; University of Southern California; Cancer Council Tasmania; World Health Organization; University of California; Fondation de France; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; University of California, San Francisco; U.S. Department of Health and Human Services; Cancer Council NSW; Susan G. Komen for the Cure; Vetenskapsrådet; Instituto de Investigación Sanitaria de Santiago de Compostela","keywords":"Breast cancer; Surgical oncology; Medicine; Gene; Oncology; Genome; Genetics; Bioinformatics; Internal medicine; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001617958,0.0004788241,0.0004560576,0.0008003974,0.0006139475,0.0005237924,0.0004012933,0.0005768627,0.001910768],"category_scores_gemma":[0.002779759,0.0002325309,0.001061777,0.001183601,0.0004167544,0.0002285056,0.0006622754,0.0004444221,0.0001435967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002056673,"about_ca_system_score_gemma":0.000313219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005098372,"about_ca_topic_score_gemma":0.004723558,"domain_scores_codex":[0.9984042,0.0007337221,0.0001039394,0.0004998666,0.0001107331,0.0001476287],"domain_scores_gemma":[0.9986285,0.0006061379,0.0003045184,0.0002119682,0.00008130894,0.0001676319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005145201,0.00003184572,0.9914209,0.00002469873,0.001194202,0.000298822,0.0001259134,0.0001555097,0.003431965,0.00009112158,0.0001360066,0.002574674],"study_design_scores_gemma":[0.00002401429,0.00009750305,0.9979092,0.000008293048,0.0004682401,0.0003202037,0.00008794917,0.0004419586,0.0002378063,0.0001230402,0.0002756193,0.000006138176],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975025,0.0004857246,0.001068313,0.00009611016,0.00001168186,0.0000101393,0.000485214,0.00001765522,0.0003226555],"genre_scores_gemma":[0.9992127,0.0000561652,0.0003750079,0.00003520347,0.000009364697,0.000008586991,0.0001943196,0.000004758736,0.0001038079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005098372,"threshold_uncertainty_score":0.01013738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05835332898509555,"score_gpt":0.3783824148364504,"score_spread":0.3200290858513548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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