{"id":"W4385701286","doi":"10.1186/s13058-023-01691-8","title":"A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry","year":2023,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; Queen's University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University Health Network; University of Toronto","funders":"Medical Research and Materiel Command; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; National Institute of Environmental Health Sciences; U.S. Army; National Institutes of Health; Hellenic Health Foundation; Xunta de Galicia; Rheinische Friedrich-Wilhelms-Universität Bonn; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Centers for Disease Control and Prevention; Institut National Du Cancer; National Center for Chronic Disease Prevention and Health Promotion; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Kuopion Yliopistollinen Sairaala; Government of Canada; University of Cambridge; Ministerio de Sanidad, Servicios Sociales e Igualdad; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; University of Crete; Institut National de la Santé et de la Recherche Médicale; Cancer Australia; Agence Nationale de la Recherche; National Institute on Aging; Robert Bosch Stiftung; Agency for Science, Technology and Research; Cancer Council South Australia; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; Cancer Council Western Australia; European Commission; Eberhard Karls Universität Tübingen; Wellcome Trust; Memorial Sloan-Kettering Cancer Center; Fondation du cancer du sein du Québec; National Breast Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Swedish Cancer Foundation; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Genome Canada; Sundhed og Sygdom, Det Frie Forskningsråd; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; National Institute for Health and Care Research; Harvard T.H. Chan School of Public Health; Division of Cancer Prevention, National Cancer Institute; Cancer Council Victoria; California Department of Public Health; Brigham and Women's Hospital; Breast Cancer Research Foundation; Cancer Research UK; Stavros Niarchos Foundation; University of Southern California; Cancer Council Tasmania; World Health Organization; University of California; Fondation de France; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; University of California, San Francisco; U.S. Department of Health and Human Services; Cancer Council NSW; Susan G. Komen for the Cure; Vetenskapsrådet; Instituto de Investigación Sanitaria de Santiago de Compostela","keywords":"Breast cancer; Surgical oncology; Medicine; Gene; Oncology; Genome; Genetics; Bioinformatics; Internal medicine; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001630551,0.0001152767,0.0002281261,0.0001232066,0.0001196964,0.000007558293,0.0002571382,0.00007249717,0.0001034649],"category_scores_gemma":[0.00007432373,0.0001078067,0.00006963554,0.0002392873,0.0001061788,0.000004223899,0.0002388422,0.000145088,0.00001021703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404793,"about_ca_system_score_gemma":0.0001351658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001385558,"about_ca_topic_score_gemma":0.000258196,"domain_scores_codex":[0.998073,0.0004893414,0.0003512933,0.0003908926,0.0002441864,0.0004513141],"domain_scores_gemma":[0.9990281,0.00007738697,0.0002164462,0.00035234,0.0002353134,0.00009036012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005984295,0.0003593673,0.8407869,0.00007206345,0.0003523639,0.000001462078,0.0007678546,0.008845251,0.1328052,0.00000119438,0.00125685,0.01415307],"study_design_scores_gemma":[0.0008210443,0.000378865,0.9922696,0.00001341069,0.00001680022,0.000004137183,0.0024295,0.0001269171,0.001320543,0.00002996018,0.002489963,0.00009924898],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975742,0.0002238072,0.00009760273,0.0003442079,0.00008916905,0.000517791,0.0009970873,0.000006773354,0.0001494039],"genre_scores_gemma":[0.9959787,0.002289935,0.00005005605,0.00001686385,0.0002969019,0.0005754452,0.00006070493,0.00003074546,0.0007006182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1514827,"threshold_uncertainty_score":0.439623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05835332898509555,"score_gpt":0.3783824148364504,"score_spread":0.3200290858513548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}