{"id":"W4385705588","doi":"10.1097/01.hs9.0000976912.69182.0b","title":"PB2554: DESIGN OF A PHASE 1B OPEN-LABEL STUDY TO ASSESS THE SAFETY, EFFICACY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF POVETACICEPT (ALPN-303) IN SUBJECTS WITH AUTOIMMUNE CYTOPENIAS (RUBY-4)","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Autoimmune hemolytic anemia; Medicine; B-cell activating factor; Rituximab; Pharmacodynamics; Pharmacokinetics; Immunology; Antibody; Pure red cell aplasia; Internal medicine; Autoantibody; Anemia; Pharmacology; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001853412,0.0003540047,0.0009822469,0.0001943144,0.00009815959,0.00005278901,0.0007613535,0.00008071281,0.000230989],"category_scores_gemma":[0.0003016058,0.0002456364,0.00004444834,0.001915779,0.0002515317,0.0001485812,0.000895367,0.0004327275,0.00003274819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001286586,"about_ca_system_score_gemma":0.003087766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001194864,"about_ca_topic_score_gemma":0.0002818199,"domain_scores_codex":[0.9966098,0.0004216395,0.0008137811,0.00059725,0.0009233972,0.0006341196],"domain_scores_gemma":[0.9974197,0.0009996556,0.0002250766,0.0008240315,0.0002894607,0.000242082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.09959183,0.09532247,0.01284056,0.005657548,0.005090389,0.009358667,0.04793344,0.01458305,0.5848849,0.0007333148,0.01113256,0.1128713],"study_design_scores_gemma":[0.6508647,0.01435536,0.01227148,0.001894123,0.001183408,0.0005115985,0.01316971,0.2438119,0.05930848,0.00004617457,0.001551877,0.0010312],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906422,0.0005455207,0.000893952,0.0005773294,0.00008720082,0.006048373,0.00003853125,0.00006463956,0.001102268],"genre_scores_gemma":[0.9961803,0.0003426823,0.0016001,0.0001553775,0.00004252286,0.0001535184,0.0000243139,0.00009112742,0.001410075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5512729,"threshold_uncertainty_score":0.9999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1137893431964197,"score_gpt":0.4204725488922121,"score_spread":0.3066832056957924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}