{"id":"W4385705588","doi":"10.1097/01.hs9.0000976912.69182.0b","title":"PB2554: DESIGN OF A PHASE 1B OPEN-LABEL STUDY TO ASSESS THE SAFETY, EFFICACY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF POVETACICEPT (ALPN-303) IN SUBJECTS WITH AUTOIMMUNE CYTOPENIAS (RUBY-4)","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Autoimmune hemolytic anemia; Medicine; B-cell activating factor; Rituximab; Pharmacodynamics; Pharmacokinetics; Immunology; Antibody; Pure red cell aplasia; Internal medicine; Autoantibody; Anemia; Pharmacology; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003713759,0.002364516,0.002746393,0.0006598671,0.00077804,0.001609668,0.001539873,0.002559627,0.007929325],"category_scores_gemma":[0.001236498,0.001013348,0.001445442,0.0005139007,0.001847877,0.001542308,0.0005034157,0.004116189,0.002460149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001964459,"about_ca_system_score_gemma":0.003462991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001281638,"about_ca_topic_score_gemma":0.002788594,"domain_scores_codex":[0.9990774,0.0003831137,0.00004617816,0.000195338,0.00009000373,0.0002078881],"domain_scores_gemma":[0.9991158,0.0001246944,0.0001476211,0.00008042479,0.00006091759,0.0004706716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.696366,0.1723622,0.003090277,0.001187021,0.001004519,0.0004623691,0.0003210823,0.00254138,0.04920053,0.0007400263,0.004742385,0.06798217],"study_design_scores_gemma":[0.438594,0.5512459,0.003286233,0.00003196216,0.0002216736,0.0001605097,0.00003921059,0.0007850343,0.002445898,0.0003422254,0.002812584,0.0000347275],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9682478,0.002430406,0.002297733,0.0008043366,0.0003409639,0.01947488,0.002401806,0.0002632221,0.003738845],"genre_scores_gemma":[0.9584697,0.001698623,0.007815794,0.002437606,0.000371995,0.01967102,0.003057656,0.00008617941,0.006391454],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.007929325,"threshold_uncertainty_score":0.02652621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1137893431964197,"score_gpt":0.4204725488922121,"score_spread":0.3066832056957924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}