{"id":"W4385726786","doi":"10.1038/s43587-023-00462-6","title":"Universal DNA methylation age across mammalian tissues","year":2023,"lang":"en","type":"article","venue":"Nature Aging","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":387,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; LGL (Canada); University of British Columbia; Acadia University; Vancouver Aquarium; University of Manitoba; Fisheries and Oceans Canada; Trent University","funders":"NHLBI Division of Intramural Research; National Heart, Lung, and Blood Institute; National Institute on Aging; Center for Information Technology; Paul G. Allen Family Foundation; Natural Environment Research Council; Department of Science and Technology, Ministry of Science and Technology, India; Jonsson Comprehensive Cancer Center; Open Philanthropy Project; National Geographic Society; Sight Research UK; Paul G. Allen Frontiers Group; U.S. Department of Health and Human Services; National Institutes of Health; Cancer Research UK","keywords":"DNA methylation; Biology; Epigenetics; Methylation; Genomic imprinting; Genetics; Gene; Developmental biology; Senescence; Evolutionary biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006604,0.0002168484,0.0002530869,0.0005734559,0.0002090648,0.0004007251,0.0002033793,0.0002514154,0.0007897546],"category_scores_gemma":[0.001543368,0.0002158901,0.0001834355,0.0006479525,0.00027312,0.000380609,0.0004684863,0.00030199,0.0002168252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000267096,"about_ca_system_score_gemma":0.0001946603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00139733,"about_ca_topic_score_gemma":0.004275155,"domain_scores_codex":[0.9996374,0.00006422779,0.00001787778,0.0002028361,0.00005721561,0.00002053215],"domain_scores_gemma":[0.9994062,0.0001870077,0.0002197271,0.00009151512,0.00007041698,0.0000252105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002523084,0.00001438328,0.2056695,0.0002800994,0.0003846371,0.0000706728,0.0003998392,0.004540852,0.6864381,0.001933094,0.0005712414,0.09944546],"study_design_scores_gemma":[0.00000897779,0.0002153493,0.7377304,0.00003414581,0.0002174657,0.0005317467,0.0001677502,0.01432278,0.2290237,0.004815299,0.01288472,0.00004776163],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8506783,0.005403829,0.1336971,0.0001742235,0.00006008521,0.00003803673,0.00432615,0.0006627982,0.004959509],"genre_scores_gemma":[0.9803634,0.0009777483,0.01657822,0.00009216584,0.00001507939,0.00002749716,0.001080955,0.00004519157,0.0008196571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139733,"threshold_uncertainty_score":0.003492594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134430523714882,"score_gpt":0.3122950395329292,"score_spread":0.3009507342957804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}