{"id":"W4385726786","doi":"10.1038/s43587-023-00462-6","title":"Universal DNA methylation age across mammalian tissues","year":2023,"lang":"en","type":"article","venue":"Nature Aging","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":387,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; LGL (Canada); University of British Columbia; Acadia University; Vancouver Aquarium; University of Manitoba; Fisheries and Oceans Canada; Trent University","funders":"NHLBI Division of Intramural Research; National Heart, Lung, and Blood Institute; National Institute on Aging; Center for Information Technology; Paul G. Allen Family Foundation; Natural Environment Research Council; Department of Science and Technology, Ministry of Science and Technology, India; Jonsson Comprehensive Cancer Center; Open Philanthropy Project; National Geographic Society; Sight Research UK; Paul G. Allen Frontiers Group; U.S. Department of Health and Human Services; National Institutes of Health; Cancer Research UK","keywords":"DNA methylation; Biology; Epigenetics; Methylation; Genomic imprinting; Genetics; Gene; Developmental biology; Senescence; Evolutionary biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002625886,0.00009967572,0.00007797177,0.00004903656,0.0001133275,0.00003791339,0.0001147541,0.0002707413,0.000009333045],"category_scores_gemma":[0.00006738098,0.0001019871,0.00005261139,0.000225527,0.00002684762,0.00000481469,0.00008927979,0.0001646059,0.00002968695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001239119,"about_ca_system_score_gemma":0.00001533091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001255456,"about_ca_topic_score_gemma":0.00005801744,"domain_scores_codex":[0.999248,0.00004196323,0.0001011853,0.0002537981,0.000130179,0.0002248651],"domain_scores_gemma":[0.9996372,0.00001387898,0.00004557669,0.0002039152,0.00005168897,0.00004774547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001187762,0.000007232378,0.002480829,0.00001312089,0.00002134194,0.0000232734,0.0003529312,0.0002281485,0.9775649,0.0002067543,0.0009200667,0.01816949],"study_design_scores_gemma":[0.0002629713,0.00004467175,0.01925482,0.000009190684,0.000009324828,9.763771e-7,0.0002473894,0.0001188377,0.7723091,0.000530101,0.2070414,0.0001712595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946396,0.001746565,0.0007392496,0.0003578905,0.0003311564,0.00009695401,0.00001350071,0.00005314661,0.002021916],"genre_scores_gemma":[0.995576,0.0002013463,0.000455669,0.00009863418,0.0003641308,0.000003286132,0.0004154982,0.0000206606,0.002864806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2061213,"threshold_uncertainty_score":0.4158912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134430523714882,"score_gpt":0.3122950395329292,"score_spread":0.3009507342957804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}