{"id":"W4385726857","doi":"10.1126/science.abq5693","title":"DNA methylation networks underlying mammalian traits","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; LGL (Canada); University of British Columbia; Acadia University; Vancouver Aquarium; University of Manitoba; Fisheries and Oceans Canada; Trent University","funders":"National Institute on Aging; University of California, Los Angeles; National Institutes of Health; Taronga Conservation Society Australia; Universität Zürich; A.H. Schultz-Stiftung zur Förderung Primatologischer Forschung; King Saud University; Department of Science and Technology, Ministry of Science and Technology, India; Leverhulme Trust; Sight Research UK; British Heart Foundation; Wellcome Trust; University of Maryland; Natural Environment Research Council; Science Foundation Ireland; UK Research and Innovation; Jonsson Comprehensive Cancer Center; National Science Foundation; Open Philanthropy Project; National Geographic Society; Cancer Research UK","keywords":"Biology; DNA methylation; Genetics; Epigenome; Epigenetics; Methylation; Gene; Retrotransposon; Phylogenetic tree; Genome; Evolutionary biology; Gene expression; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002193839,0.0001093715,0.0002377665,0.0007983072,0.0002595759,0.0002747605,0.0001700288,0.000212435,0.0009206241],"category_scores_gemma":[0.0007373439,0.000162264,0.0002198747,0.0007717009,0.0002413777,0.0002865618,0.0003453877,0.0002206116,0.0001922814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002361043,"about_ca_system_score_gemma":0.0001813645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002150339,"about_ca_topic_score_gemma":0.004258698,"domain_scores_codex":[0.9998185,0.00003174089,0.000008146178,0.00009575508,0.00002029748,0.00002569215],"domain_scores_gemma":[0.9996731,0.000103026,0.0001220345,0.00002525533,0.00004958887,0.0000270366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005960586,0.00003028181,0.4123402,0.0004175034,0.0006494834,0.000266271,0.001247704,0.01141147,0.491439,0.004811311,0.0006462958,0.07614444],"study_design_scores_gemma":[0.00001066094,0.00008122062,0.9624864,0.00002365152,0.0001478131,0.0002789265,0.0001795188,0.01572686,0.01191764,0.005772833,0.003349218,0.00002521281],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893619,0.001253905,0.006530595,0.00006704157,0.000002750259,0.000007238073,0.001264712,0.00005571846,0.001456045],"genre_scores_gemma":[0.9970213,0.0003196424,0.00135089,0.00002329702,0.000003417415,0.000009301304,0.0009275842,0.000007374375,0.0003372374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002150339,"threshold_uncertainty_score":0.00427568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03933988957300001,"score_gpt":0.3195705049936787,"score_spread":0.2802306154206787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}