{"id":"W4385726857","doi":"10.1126/science.abq5693","title":"DNA methylation networks underlying mammalian traits","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; LGL (Canada); University of British Columbia; Acadia University; Vancouver Aquarium; University of Manitoba; Fisheries and Oceans Canada; Trent University","funders":"National Institute on Aging; University of California, Los Angeles; National Institutes of Health; Taronga Conservation Society Australia; Universität Zürich; A.H. Schultz-Stiftung zur Förderung Primatologischer Forschung; King Saud University; Department of Science and Technology, Ministry of Science and Technology, India; Leverhulme Trust; Sight Research UK; British Heart Foundation; Wellcome Trust; University of Maryland; Natural Environment Research Council; Science Foundation Ireland; UK Research and Innovation; Jonsson Comprehensive Cancer Center; National Science Foundation; Open Philanthropy Project; National Geographic Society; Cancer Research UK","keywords":"Biology; DNA methylation; Genetics; Epigenome; Epigenetics; Methylation; Gene; Retrotransposon; Phylogenetic tree; Genome; Evolutionary biology; Gene expression; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007170308,0.00006686652,0.0000487978,0.00008248651,0.000205328,0.00005184374,0.000189993,0.00005848228,0.000007627929],"category_scores_gemma":[0.0001079193,0.00006516028,0.00002944299,0.0006750618,0.0001337018,0.000007179493,0.00007522327,0.00004046669,0.00002535969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001099651,"about_ca_system_score_gemma":0.00006834537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002889288,"about_ca_topic_score_gemma":0.00001293609,"domain_scores_codex":[0.9991361,0.00002416792,0.0001081678,0.0002902725,0.0001876927,0.0002535851],"domain_scores_gemma":[0.999648,0.000009999215,0.00004049771,0.0001614212,0.00006593948,0.00007413587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000002653669,0.000003627964,0.0005901819,0.000001805706,0.000001600517,5.355494e-7,0.00003250532,0.004715486,0.966974,0.0001766251,0.00004781169,0.02745322],"study_design_scores_gemma":[0.0001944134,0.0001251765,0.206387,0.000006661015,0.000005750132,0.00000108893,0.00008876411,0.01264277,0.7676618,0.001324648,0.01134691,0.0002150151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773036,0.0003226427,0.02005336,0.0001305107,0.0002504581,0.00008360303,0.000001637498,0.00002794592,0.001826242],"genre_scores_gemma":[0.9986142,0.00009961248,0.0005219889,0.00005075159,0.0001040676,0.000005768462,0.00002420746,0.000008043065,0.0005713822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2057969,"threshold_uncertainty_score":0.2657159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03933988957300001,"score_gpt":0.3195705049936787,"score_spread":0.2802306154206787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}