{"id":"W4385728001","doi":"10.1101/2023.08.09.550677","title":"Heterogeneity of synaptic NMDA receptor responses within individual lamina I pain processing neurons across sex in rats and humans","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Carleton University; Ottawa Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Neuroscience; Excitatory postsynaptic potential; NMDA receptor; AMPA receptor; Glutamatergic; Biology; Synaptic plasticity; Neurotransmission; Inhibitory postsynaptic potential; Glutamate receptor; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001769085,0.0002105983,0.0002692911,0.0003827448,0.0001342343,0.0002340867,0.0001440143,0.0001662175,0.001427924],"category_scores_gemma":[0.0005572684,0.0001005252,0.000198466,0.0001373476,0.0002449053,0.0001513277,0.0001919085,0.0001520426,0.0001812089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001049801,"about_ca_system_score_gemma":0.00007201345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006873492,"about_ca_topic_score_gemma":0.0007636386,"domain_scores_codex":[0.9998422,0.00001830507,0.00001498564,0.00007514124,0.00002767003,0.0000216612],"domain_scores_gemma":[0.9997856,0.00004030044,0.00009580372,0.00002691751,0.00002395589,0.00002740739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003946777,0.0001850496,0.5725608,0.0002694244,0.000513544,0.003473588,0.00126735,0.0002764246,0.3252639,0.0005703764,0.001057085,0.0906156],"study_design_scores_gemma":[0.00002002357,0.0006215951,0.9840714,0.00002661627,0.00009982734,0.004555835,0.0002876054,0.000272278,0.008763051,0.000172934,0.001090154,0.00001868949],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979253,0.0004860112,0.0008005121,0.00002216145,0.000009199109,0.000007523454,0.0003012875,0.00001762326,0.0004303574],"genre_scores_gemma":[0.9987292,0.0002847622,0.0003958897,0.00005984661,0.000007191376,0.0000127052,0.0002192205,0.00001512242,0.0002762522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001427924,"threshold_uncertainty_score":0.004776835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04068908344038671,"score_gpt":0.2881924404122744,"score_spread":0.2475033569718877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}