{"id":"W4385728061","doi":"10.3389/fmicb.2023.1175679","title":"HTLV-1 p12 modulates the levels of prion protein (PrPC) in CD4+ T cells","year":2023,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Universidade Federal do Rio de Janeiro","keywords":"Tropical spastic paraparesis; Biology; Immune system; Western blot; Flow cytometry; Downregulation and upregulation; Inflammation; Virology; Immunology; Myelopathy; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005403582,0.0002269563,0.0005534342,0.0003756879,0.0001127738,0.000004160523,0.0004179289,0.0004408841,0.00008399209],"category_scores_gemma":[0.00005347239,0.0001554287,0.000106287,0.0005264225,0.0007233845,0.00003762072,0.0002485392,0.0004740173,0.0002544666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006425548,"about_ca_system_score_gemma":0.00004991157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000191063,"about_ca_topic_score_gemma":0.0001765839,"domain_scores_codex":[0.9980447,0.0004282188,0.0005050158,0.0003844833,0.00001678531,0.0006208212],"domain_scores_gemma":[0.9993767,0.0001100778,0.0001599321,0.0003066042,0.00003652216,0.0000102013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001104341,0.00007196873,0.01515745,0.00003679372,0.0001012437,0.000007949411,0.001273862,0.00004953364,0.962557,0.00008539966,0.01686698,0.003681382],"study_design_scores_gemma":[0.002050677,0.0002339782,0.02252994,0.0001083726,0.00002251419,0.00002014295,0.002031115,0.00002238236,0.9193611,0.001300748,0.05197317,0.0003458525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885122,0.00732134,0.0001134553,0.0006123286,0.002339197,0.0006514631,0.0001360245,0.00005607248,0.0002579224],"genre_scores_gemma":[0.9945248,0.0004299849,0.0002892755,0.00008259079,0.00002441772,0.0000567331,0.00006484924,0.00001935156,0.00450804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04319589,"threshold_uncertainty_score":0.6338199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170832160356798,"score_gpt":0.212408354918566,"score_spread":0.2007000333149981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}