{"id":"W4385732661","doi":"10.1371/journal.pone.0288994","title":"Knockdown resistance allele L1014F introduced by CRISPR/Cas9 is not associated with altered vector competence of Anopheles gambiae for o’nyong nyong virus","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Economic and Social Research Council; Medical Research Council","keywords":"Biology; Knockdown resistance; Virology; Genetics; Anopheles gambiae; Allele; Genotype; Vector (molecular biology); Malaria; Deltamethrin; Immunology; Gene; Bendiocarb; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001079248,0.0002677617,0.0002483885,0.0002068471,0.0001235413,0.0002516665,0.0001810471,0.0002312647,0.002257745],"category_scores_gemma":[0.0001595811,0.0001202418,0.0001785694,0.00008865577,0.0002013644,0.0001060258,0.0001901553,0.0004376228,0.0002710497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001715285,"about_ca_system_score_gemma":0.000164567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002164842,"about_ca_topic_score_gemma":0.004915151,"domain_scores_codex":[0.9998425,0.00002174868,0.000016739,0.00004089593,0.00004849519,0.00002961434],"domain_scores_gemma":[0.9998602,0.00002582517,0.00005943384,0.00001384013,0.000009369943,0.0000312366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007173267,0.00003102852,0.0004865656,0.00003881211,0.000007783176,0.00009841857,0.00002221819,0.00002791615,0.9978891,0.00006081223,0.00008063274,0.001184974],"study_design_scores_gemma":[0.00005406537,0.0007245133,0.07832827,0.00004462029,0.00007538451,0.001695716,0.0002833828,0.002693437,0.9056441,0.0001043659,0.01031863,0.00003354141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960607,0.0001867133,0.00142958,0.00004521431,0.00002485043,0.00003022667,0.0005296557,0.00008354014,0.00160968],"genre_scores_gemma":[0.9931641,0.0001545772,0.002103601,0.00006062215,0.000002479281,0.00004534547,0.0008640942,0.00004615673,0.00355892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002257745,"threshold_uncertainty_score":0.007552862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04069276445684395,"score_gpt":0.2538838960065938,"score_spread":0.2131911315497498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}