{"id":"W4385737921","doi":"10.3390/cancers15164043","title":"Recent Advances in Renal Tumors with TSC/mTOR Pathway Abnormalities in Patients with Tuberous Sclerosis Complex and in the Sporadic Setting","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Rockyview General Hospital; University of Calgary","funders":"National Cancer Institute; National Institutes of Health","keywords":"Tuberous sclerosis; Renal cell carcinoma; Eosinophilic; Pathology; PI3K/AKT/mTOR pathway; Cancer research; Immunohistochemistry; Medicine; Stroma; SMARCB1; Germline; Everolimus; Biology; Oncology; Gene; Epigenetics; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004113468,0.0005539931,0.000905243,0.003086779,0.0001779755,0.0007112612,0.0004471888,0.0005815186,0.002603072],"category_scores_gemma":[0.0007920529,0.0001802711,0.0004176073,0.002516723,0.0002909972,0.0009691701,0.0005317151,0.001006095,0.001043228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003902348,"about_ca_system_score_gemma":0.0006068954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007301912,"about_ca_topic_score_gemma":0.001386247,"domain_scores_codex":[0.9998488,0.00002525233,0.0000317798,0.00003456571,0.00004583092,0.00001364942],"domain_scores_gemma":[0.9994672,0.0002762584,0.00008346258,0.00001427186,0.0001200057,0.00003883862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007976219,0.00003606802,0.0006064542,0.01225859,0.0001093001,0.0004902694,0.00005920463,0.0002579395,0.001270712,0.001336904,0.01703652,0.9664583],"study_design_scores_gemma":[0.00001799405,0.0001224227,0.003643626,0.00491369,0.0004835271,0.009424299,0.000119517,0.0001960691,0.0009941814,0.00160121,0.9784473,0.00003626588],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001964355,0.9986171,0.0001189956,0.000241656,0.0001186864,0.000001754706,0.00001607769,0.000008456367,0.0006807868],"genre_scores_gemma":[0.001330329,0.9976395,0.0002159231,0.0001973102,0.0002793472,0.000002675362,0.00003904614,0.000001909987,0.0002939676],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003086779,"threshold_uncertainty_score":0.008708179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09265427558148655,"score_gpt":0.325381964192411,"score_spread":0.2327276886109245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}