{"id":"W4385737921","doi":"10.3390/cancers15164043","title":"Recent Advances in Renal Tumors with TSC/mTOR Pathway Abnormalities in Patients with Tuberous Sclerosis Complex and in the Sporadic Setting","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Rockyview General Hospital; University of Calgary","funders":"National Cancer Institute; National Institutes of Health","keywords":"Tuberous sclerosis; Renal cell carcinoma; Eosinophilic; Pathology; PI3K/AKT/mTOR pathway; Cancer research; Immunohistochemistry; Medicine; Stroma; SMARCB1; Germline; Everolimus; Biology; Oncology; Gene; Epigenetics; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009362387,0.0005533641,0.001772902,0.0007357517,0.00009463597,0.00006966191,0.000379344,0.0001415512,0.0000494495],"category_scores_gemma":[0.0001148248,0.0003358307,0.00007855866,0.002062428,0.0004186179,0.0001977698,0.0001097966,0.001145262,0.000008313158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002799167,"about_ca_system_score_gemma":0.001657167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009959275,"about_ca_topic_score_gemma":0.008123794,"domain_scores_codex":[0.9960879,0.0004516774,0.0008557075,0.0007566669,0.0009648673,0.000883155],"domain_scores_gemma":[0.998452,0.0004332642,0.0003162658,0.0005329161,0.0001053343,0.0001601953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000568043,0.00008795314,0.05256528,0.01156954,0.00008023265,0.0002495959,0.001550986,0.0001886845,4.344654e-7,0.00002011132,0.0002471633,0.932872],"study_design_scores_gemma":[0.00797941,0.001736394,0.3953938,0.1858775,0.0002410052,0.0001304354,0.003179443,0.00007824811,0.000001506741,0.00001487681,0.4041235,0.001243873],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1116826,0.8846303,6.003887e-7,0.0001216271,0.00005612809,0.00300982,0.0001342968,0.00004836619,0.0003163325],"genre_scores_gemma":[0.0126087,0.9858098,0.0001280047,0.0001544191,0.00008757845,0.0007581091,0.0002874001,0.000123942,0.00004201907],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9316281,"threshold_uncertainty_score":0.9999094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09265427558148655,"score_gpt":0.325381964192411,"score_spread":0.2327276886109245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}