{"id":"W4385738280","doi":"10.1016/j.ccell.2023.07.007","title":"Proteogenomic insights suggest druggable pathways in endometrial carcinoma","year":2023,"lang":"en","type":"article","venue":"Cancer Cell","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas; National Institute of General Medical Sciences; Battelle; U.S. Department of Defense; U.S. Department of Energy; Pacific Northwest National Laboratory; Leidos","keywords":"Druggability; Cancer research; Wnt signaling pathway; Biology; Protein kinase B; Phosphorylation; Carcinoma; Bioinformatics; Immunotherapy; Medicine; Oncology; Internal medicine; Signal transduction; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002243905,0.0002807897,0.0003020787,0.0008891281,0.0001952062,0.000564037,0.0001320851,0.0001779707,0.0006341451],"category_scores_gemma":[0.0003698683,0.0001550082,0.0003156384,0.0007667387,0.0001665179,0.0001706367,0.0004277636,0.0002323764,0.0001757809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002382671,"about_ca_system_score_gemma":0.0001960732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001245735,"about_ca_topic_score_gemma":0.002350393,"domain_scores_codex":[0.9999001,0.00001670401,0.000008749869,0.00002902762,0.00002259661,0.00002285765],"domain_scores_gemma":[0.9999052,0.00001656134,0.00003627918,0.00001223376,0.00001270652,0.0000169518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001236149,0.0001230552,0.5680978,0.000264397,0.0005275385,0.001507352,0.0002248878,0.007071142,0.357397,0.001200698,0.001568804,0.06078125],"study_design_scores_gemma":[0.00003580903,0.00017442,0.9329286,0.00004351415,0.0002852578,0.002593326,0.000286365,0.02267062,0.0322836,0.002895568,0.005767103,0.00003574011],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942919,0.001411573,0.001546569,0.0001230132,0.000004712919,0.0000116644,0.001949921,0.00003323911,0.0006274126],"genre_scores_gemma":[0.9962114,0.0004945566,0.001382629,0.00006236872,0.000004795061,0.00001157546,0.001512856,0.00000996625,0.0003099543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245735,"threshold_uncertainty_score":0.00247699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02113248351635116,"score_gpt":0.2496062195136619,"score_spread":0.2284737359973108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}