{"id":"W4385738280","doi":"10.1016/j.ccell.2023.07.007","title":"Proteogenomic insights suggest druggable pathways in endometrial carcinoma","year":2023,"lang":"en","type":"article","venue":"Cancer Cell","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas; National Institute of General Medical Sciences; Battelle; U.S. Department of Defense; U.S. Department of Energy; Pacific Northwest National Laboratory; Leidos","keywords":"Druggability; Cancer research; Wnt signaling pathway; Biology; Protein kinase B; Phosphorylation; Carcinoma; Bioinformatics; Immunotherapy; Medicine; Oncology; Internal medicine; Signal transduction; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001719339,0.000191145,0.0001995659,0.0001156143,0.00005993722,0.00002466337,0.0002954489,0.0001794802,0.0001445963],"category_scores_gemma":[0.00003822561,0.0001953913,0.00008948737,0.0004229644,0.00005441504,0.000005796473,0.0001361041,0.0001254719,0.00009676828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802676,"about_ca_system_score_gemma":0.0003716246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005803657,"about_ca_topic_score_gemma":0.0005082732,"domain_scores_codex":[0.9986143,0.00005935697,0.0002461403,0.0005059127,0.0001531281,0.0004211683],"domain_scores_gemma":[0.9993507,0.00002421525,0.00008504418,0.0003916356,0.00005244291,0.00009595943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001210653,0.00003247066,0.00583447,0.00004650408,0.00001418233,0.00002388746,0.0001902938,0.0006808679,0.986982,0.00001396585,0.00512084,0.0009393992],"study_design_scores_gemma":[0.001746676,0.0001763305,0.002090333,0.00001980093,0.0000101057,0.000001515508,0.00008460359,0.0001203485,0.9104653,0.00006173163,0.08494054,0.000282701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864284,0.007268142,0.00002013333,0.00003587065,0.000910072,0.0004363422,0.00006607874,0.00003864216,0.004796295],"genre_scores_gemma":[0.9958084,0.0009137675,0.0000637684,0.0001262735,0.0009233029,0.0003598084,0.0001162226,0.00005023642,0.001638266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07981969,"threshold_uncertainty_score":0.7967825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02113248351635116,"score_gpt":0.2496062195136619,"score_spread":0.2284737359973108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}