{"id":"W4385739932","doi":"10.1097/01.hs9.0000968596.43178.c6","title":"P422: TARGETING THE WT1MUT-MIR-193A TRANSCRIPTIONAL AXIS WITH INT-1B3, A NOVEL LIPID NANOPARTICLE-FORMULATED MIR-193A-3P MIMIC IN ACUTE MYELOID LEUKEMIA","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"","keywords":"Cancer research; Myeloid leukemia; DNA methylation; Epigenetics; microRNA; Decitabine; Biology; Methylation; Gene silencing; Leukemia; Gene; Immunology; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001212326,0.0003068527,0.0001812321,0.0001316158,0.0001163143,0.0002162263,0.0001750101,0.0003248338,0.0008484392],"category_scores_gemma":[0.00009239981,0.0001271387,0.0001828418,0.00009330782,0.0001570587,0.0001406149,0.0001582363,0.0003511466,0.0003527455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002156988,"about_ca_system_score_gemma":0.0001645387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004960506,"about_ca_topic_score_gemma":0.0004675252,"domain_scores_codex":[0.9999199,0.00001022768,0.000003892867,0.00002161628,0.00002918025,0.00001513756],"domain_scores_gemma":[0.9999819,0.000002354954,0.000005236372,0.000001695752,0.000002655631,0.000006173597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002442506,0.00004347181,0.00007145689,0.00003611416,0.000005890844,0.00004662955,0.00001107784,0.0002211687,0.9962478,0.0001009931,0.0001658143,0.002805206],"study_design_scores_gemma":[0.00006440786,0.0006733644,0.0007026429,0.00000354024,0.0000191139,0.00018896,0.000009511799,0.002495107,0.9919316,0.00004578452,0.003858557,0.000007279024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869879,0.001483819,0.007333898,0.0001870473,0.00007051531,0.00009970824,0.0004354794,0.0002713591,0.003130328],"genre_scores_gemma":[0.9919172,0.0006694632,0.004160861,0.00008943976,0.00001012096,0.0001120853,0.0004518075,0.0000494298,0.002539596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008484392,"threshold_uncertainty_score":0.002838314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02372331874045983,"score_gpt":0.2759222441078383,"score_spread":0.2521989253673785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}