{"id":"W4385741538","doi":"10.1038/s41422-023-00863-7","title":"Studying human embryo development with E-assembloids","year":2023,"lang":"en","type":"letter","venue":"Cell Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Gairdner Foundation; Hospital for Sick Children","funders":"","keywords":"Biology; Embryo; Computational biology; Evolutionary biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002218844,0.0004688971,0.0004006672,0.0006569187,0.0007445342,0.0002410427,0.001555385,0.001078032,0.0001039852],"category_scores_gemma":[0.00007783407,0.0004074899,0.0001184163,0.0006713711,0.000323951,0.000004152293,0.001593433,0.003472273,0.001440675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021218,"about_ca_system_score_gemma":0.001155748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008004878,"about_ca_topic_score_gemma":0.0001004604,"domain_scores_codex":[0.992985,0.0006592108,0.0004111438,0.001441622,0.002603098,0.001899893],"domain_scores_gemma":[0.9974921,0.0001440359,0.00009298717,0.001344202,0.0007056756,0.0002210141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003556154,0.0000635504,0.0001952683,0.0004943681,0.0001225377,0.0008682588,0.00006000294,0.000005728366,0.2379153,8.127868e-7,0.7597104,0.0005281398],"study_design_scores_gemma":[0.0004922277,0.0004983534,0.0002777925,0.0001130963,0.000009412556,0.00001101068,0.0001069033,0.000002926077,0.1706105,0.000008827799,0.8274084,0.0004605916],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.7367101,0.00305162,0.0002481901,0.1193326,0.000766433,0.005986821,0.00009490913,0.0003364931,0.1334728],"genre_scores_gemma":[0.07280242,0.0006662862,0.0007409549,0.02573326,0.00657841,0.001253406,0.004917455,0.0008731417,0.8864347],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.7529619,"threshold_uncertainty_score":0.9998377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1018663682177785,"score_gpt":0.3620275655881781,"score_spread":0.2601611973703996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}