{"id":"W4385751553","doi":"10.1007/s00216-023-04885-3","title":"Detection of synthetic analogues of insulin-like growth factor 1 in different biological fluids by liquid chromatography quadrupole time-of-flight mass spectrometry: comparison of different immunoaffinity protocols","year":2023,"lang":"en","type":"article","venue":"Analytical and Bioanalytical Chemistry","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"World Anti-Doping Agency","keywords":"Chromatography; Analyte; Mass spectrometry; Chemistry; Detection limit; Matrix (chemical analysis); Ion suppression in liquid chromatography–mass spectrometry; Extraction (chemistry); Analytical Chemistry (journal); Liquid chromatography–mass spectrometry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001249808,0.0006743493,0.000389751,0.0005799242,0.0004752294,0.0006760467,0.0007214947,0.0009423628,0.0007121568],"category_scores_gemma":[0.001839267,0.0003090974,0.0003677655,0.0004156998,0.0006899389,0.0007141141,0.0004147971,0.0009111818,0.0004044824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006212634,"about_ca_system_score_gemma":0.000800999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006167734,"about_ca_topic_score_gemma":0.00112334,"domain_scores_codex":[0.9990149,0.0002244379,0.0000573186,0.0002208381,0.0003878698,0.00009473412],"domain_scores_gemma":[0.9993893,0.0002384722,0.0001173732,0.00004334217,0.0001318307,0.00007961338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003492115,0.00004616424,0.0002686057,0.00009348647,0.00001944712,0.00002583258,0.00002847285,0.00005833626,0.9958231,0.0001243009,0.00007128169,0.003091621],"study_design_scores_gemma":[0.00004057565,0.0003793176,0.001923934,0.00001321204,0.00003238912,0.0002856746,0.00003730117,0.0009967466,0.9941755,0.0001287339,0.001968281,0.00001851767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8900907,0.01329117,0.09104382,0.0006914182,0.0005201385,0.000426461,0.0007223784,0.0005424073,0.002671543],"genre_scores_gemma":[0.8474113,0.009233093,0.1351462,0.001935125,0.0001974539,0.0007913466,0.001490286,0.0001621523,0.003632972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001249808,"threshold_uncertainty_score":0.006609678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02467606516951036,"score_gpt":0.2803751124102093,"score_spread":0.255699047240699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}