{"id":"W4385751567","doi":"10.1093/jnci/djad155","title":"Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors","year":2023,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genital Health and Disease","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Medicine; Nivolumab; Common Terminology Criteria for Adverse Events; Penile cancer; Internal medicine; Pembrolizumab; Oncology; Interquartile range; Adverse effect; Ipilimumab; Response Evaluation Criteria in Solid Tumors; Cancer; Clinical trial; Phases of clinical research; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005476348,0.0001096391,0.0003257834,0.00004721138,0.00009475612,0.000004648023,0.0001717616,0.000053592,0.000029953],"category_scores_gemma":[0.0004894867,0.0000668322,0.0002824279,0.0005478751,0.0001778603,0.0001420444,0.00009595433,0.0002608107,6.078163e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005079367,"about_ca_system_score_gemma":0.0025347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001487635,"about_ca_topic_score_gemma":0.0002392356,"domain_scores_codex":[0.9979304,0.00003855097,0.0009738252,0.0001229332,0.0007820384,0.0001522366],"domain_scores_gemma":[0.9983118,0.000103895,0.0008133572,0.000130052,0.0005201424,0.0001208024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01298857,0.0006535944,0.9047366,0.001093013,0.0004001021,0.0003608791,0.002174722,0.03131758,0.01209117,0.0001773721,0.01739163,0.01661472],"study_design_scores_gemma":[0.003648836,0.0000777028,0.9883842,0.0005494457,0.00008949528,0.0001726942,0.0002418034,0.0001614664,0.002290977,0.0004871092,0.003829004,0.00006722423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844528,0.006766215,0.000002946624,0.00685954,0.0009940908,0.0002887624,0.0003638077,0.000005598019,0.0002662253],"genre_scores_gemma":[0.9981034,0.0006563601,0.0001625915,0.000340745,0.0006085838,0.000009463045,0.00001902355,0.000007052308,0.00009278626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08364759,"threshold_uncertainty_score":0.4496449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03154213775347712,"score_gpt":0.3521227347874381,"score_spread":0.3205805970339609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}