{"id":"W4385755340","doi":"10.1139/bcb-2022-0374","title":"Modulating the immune system as a therapeutic target for myelodysplastic syndromes and acute myeloid leukemia","year":2023,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences","keywords":"Immune system; Myelodysplastic syndromes; Myeloid leukemia; Myeloid; Immunology; Innate immune system; Haematopoiesis; Immunotherapy; Leukemia; Medicine; Cancer research; Progenitor cell; Chimeric antigen receptor; Biology; Stem cell; Bone marrow","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003770806,0.0005278205,0.001368571,0.0000706288,0.0004739301,0.00003800838,0.0003208304,0.001138279,0.00002129059],"category_scores_gemma":[0.00004734477,0.0003384771,0.0003057417,0.00014236,0.0003938671,0.0000278344,0.0002274289,0.0004006609,0.00006268216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001034662,"about_ca_system_score_gemma":0.0002155314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002103392,"about_ca_topic_score_gemma":2.496999e-7,"domain_scores_codex":[0.9979298,0.0002290995,0.0006754622,0.0006587273,0.00002413297,0.0004827935],"domain_scores_gemma":[0.9982994,0.0007157068,0.0005014816,0.0004097319,0.00004280209,0.00003094019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001366221,0.00004754786,0.000008508412,0.03327665,0.003667267,0.000008692764,0.0001303873,0.000001678535,0.308374,0.002007048,0.0002021943,0.6521394],"study_design_scores_gemma":[0.001205711,0.0004296872,0.00001702198,0.004011309,0.002730782,0.001220252,0.0002906868,0.00007219819,0.05239432,0.0002496229,0.9364758,0.0009026071],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003693756,0.9943681,0.0000551989,0.00002215375,0.0005146493,0.0007723487,0.0002375946,0.00009880173,0.000237394],"genre_scores_gemma":[0.04572498,0.9483427,0.00002622566,0.0000128249,0.000102461,0.0003671948,0.001588057,0.00005950122,0.003776087],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9362736,"threshold_uncertainty_score":0.9999067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02541109087250657,"score_gpt":0.2776918401078912,"score_spread":0.2522807492353846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}