{"id":"W4385755788","doi":"10.1101/2023.08.08.552477","title":"A bacterial sialidase mediates early life colonization by a pioneering gut commensal","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"University of California, San Diego; Family Larsson‐Rosenquist Foundation; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Institute of Diabetes and Digestive and Kidney Diseases; Chiba University; Hartwell Foundation","keywords":"Colonization; Biology; Bacteroides fragilis; Microbiology; Commensalism; Microbiome; Bacteroides; Mucin; Mucus; Glycan; Bacteria; Ecology; Antibiotics; Glycoprotein; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260496,0.0002448245,0.0001331837,0.0001155287,0.0001180525,0.0002261056,0.000142529,0.0002601262,0.001045671],"category_scores_gemma":[0.0001101112,0.0000733732,0.0001418929,0.00005227659,0.0001921558,0.00013285,0.000302179,0.0003033208,0.0003265407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000221295,"about_ca_system_score_gemma":0.0001945976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004806489,"about_ca_topic_score_gemma":0.0004687285,"domain_scores_codex":[0.9999486,0.00000743698,0.000002509513,0.00001148606,0.00001124559,0.00001875929],"domain_scores_gemma":[0.999945,0.000005872004,0.0000128837,0.000007513159,0.000006724079,0.00002204562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008873932,0.00001056418,0.001011638,0.00002083217,0.000002590874,0.00009118499,0.00001070911,0.00004405644,0.9971495,0.0003125409,0.00006605561,0.001191573],"study_design_scores_gemma":[0.00001923941,0.000161404,0.02057594,0.000009349891,0.000007619248,0.0003611156,0.00006797006,0.001832615,0.9735215,0.0004168256,0.0030196,0.000006796815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909953,0.001320416,0.005269662,0.0001985582,0.00005486926,0.00001080186,0.0002131082,0.00007610901,0.001861086],"genre_scores_gemma":[0.9948843,0.0004226046,0.00209242,0.00003835243,0.00001348403,0.000008198844,0.0001810719,0.00001172311,0.002347847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001045671,"threshold_uncertainty_score":0.003498137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293274638836818,"score_gpt":0.2275651729227345,"score_spread":0.2146324265343663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}