{"id":"W4385758746","doi":"10.3390/polym15163382","title":"Anti-Melanogenesis and Anti-Photoaging Effects of the Sulfated Polysaccharides Isolated from the Brown Seaweed Padina boryana","year":2023,"lang":"en","type":"article","venue":"Polymers","topic":"Seaweed-derived Bioactive Compounds","field":"Agricultural and Biological Sciences","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Science Foundation of Qingdao; Postdoctoral Innovation Project of Shandong Province; Korea Basic Science Institute","keywords":"HaCaT; Photoaging; Reactive oxygen species; Antioxidant; Melanin; Nutraceutical; Polysaccharide; Chemistry; Fucoidan; Cosmeceutical; Dermal fibroblast; Biochemistry; Biology; Fibroblast; In vitro; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001594211,0.0001938226,0.0002523655,0.00002084674,0.0003900148,0.00006752621,0.000462621,0.00009276211,0.00008325641],"category_scores_gemma":[0.0001113944,0.00006055957,0.000129375,0.001114152,0.0002724221,0.00008555941,0.0002218814,0.0001211815,0.000013322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001778989,"about_ca_system_score_gemma":0.00001309452,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01391966,"about_ca_topic_score_gemma":0.0003730556,"domain_scores_codex":[0.9986686,0.000208053,0.0001972576,0.0003399867,0.0002339512,0.0003522068],"domain_scores_gemma":[0.9985609,0.001044333,0.0001382635,0.000139072,0.00004098846,0.00007642098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001616787,0.00001637086,0.1105344,0.000005715603,0.00007607443,0.000003343534,0.0002015711,6.091236e-7,0.8758027,0.000005673226,0.0001884971,0.0131489],"study_design_scores_gemma":[0.0001235767,0.00003297738,0.6262784,0.00003148298,0.00003974634,0.000001669816,0.0004614971,0.0001355088,0.3724984,0.00002489738,0.000263044,0.0001088098],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949405,0.001232472,0.000001054993,0.002943852,0.0002932991,0.0002802085,0.00007760487,0.0001215109,0.0001095424],"genre_scores_gemma":[0.9991522,0.0001719781,0.000003106875,0.0003867879,0.00009054205,0.000009141148,0.00002992872,0.000003255979,0.0001530609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.515744,"threshold_uncertainty_score":0.9926468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317995844045189,"score_gpt":0.2043313574611025,"score_spread":0.1911513990206506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}