{"id":"W4385762364","doi":"10.1038/s41598-023-40373-5","title":"Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Science Foundation of Hunan Province; National Natural Science Foundation of China","keywords":"Nonalcoholic fatty liver disease; Endocrinology; Internal medicine; AMPK; Lipotoxicity; Autophagy; Macrophage migration inhibitory factor; Fatty liver; Lipid metabolism; Medicine; Apoptosis; Liver disease; Insulin resistance; Diabetes mellitus; Chemistry; Disease; Cytokine; Biochemistry; Protein kinase A; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005199451,0.0003396827,0.0003208217,0.0003868771,0.0008255003,0.0002920768,0.0001585287,0.0001967585,0.0009559508],"category_scores_gemma":[0.0004736437,0.0002985139,0.0001443815,0.0004622194,0.0004051602,0.0004183134,0.0002846261,0.0003056794,0.0008161959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008705418,"about_ca_system_score_gemma":0.0000993639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001444931,"about_ca_topic_score_gemma":0.0001075918,"domain_scores_codex":[0.997218,0.0002091287,0.0006821525,0.001133476,0.0001954149,0.0005619017],"domain_scores_gemma":[0.9983931,0.0001669527,0.0004358108,0.0006624585,0.000195525,0.0001461681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006731789,0.00007232663,0.01824052,0.0000657847,0.00005995901,0.0004007389,0.001240358,0.000008640641,0.9615766,0.00001571208,0.01440606,0.003845965],"study_design_scores_gemma":[0.0004352729,0.00009609085,0.1912539,0.0001251105,0.00004920545,0.00007698566,0.0002779117,0.0001102739,0.7952172,0.000287151,0.01160204,0.0004688955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885046,0.0006541863,0.00004028117,0.0002355804,0.009562348,0.0005465119,0.00005494877,0.0003625544,0.00003892989],"genre_scores_gemma":[0.9904589,0.00001957019,0.00003428484,0.00004710886,0.0001503125,0.00008173198,0.0006196475,0.00003643335,0.008551994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1730134,"threshold_uncertainty_score":0.9999618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02361905929180055,"score_gpt":0.246590331397205,"score_spread":0.2229712721054044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}