{"id":"W4385765322","doi":"10.1016/j.omtm.2023.08.004","title":"Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stanford Maternal and Child Health Research Institute; National Center for Research Resources; National Institutes of Health; American Laryngological, Rhinological and Otological Society; American Society of Pediatric Otolaryngology; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Stanford University; National Institute on Deafness and Other Communication Disorders; American College of Surgeons; American Otological Society","keywords":"Cochlea; Capsid; Selection (genetic algorithm); Biology; Promoter; Virology; Gene; Genetics; Virus; Computer science; Neuroscience; Artificial intelligence; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006577602,0.0002486642,0.0006000288,0.0001935625,0.0001128818,0.0000196145,0.0004450012,0.0001818944,0.00001292361],"category_scores_gemma":[0.004175012,0.0001889618,0.0001918701,0.001030545,0.0005236694,0.00002767651,0.0002677933,0.0003505325,0.000006078214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003581512,"about_ca_system_score_gemma":0.00031492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001498285,"about_ca_topic_score_gemma":0.000002821205,"domain_scores_codex":[0.994277,0.002758969,0.00128424,0.0006339391,0.0006503836,0.0003954665],"domain_scores_gemma":[0.9965425,0.00219807,0.0004654322,0.0005326797,0.000137599,0.0001237324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002014354,0.0002543503,0.001385905,0.00006349056,0.00005302476,0.000005970089,0.001297042,0.0003340384,0.8713634,0.0002424716,0.00001722463,0.1247817],"study_design_scores_gemma":[0.001065361,0.0006074493,0.06972834,0.0000731977,0.00001984261,0.00000497566,0.00005437246,0.001056188,0.9256472,0.0002322118,0.00133368,0.0001771585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820344,0.0001566149,0.01622625,0.0001991639,0.0003620166,0.0008617361,0.000002783952,0.00005577773,0.0001012631],"genre_scores_gemma":[0.9014019,0.0003761966,0.0977434,0.000305369,0.00001995946,0.00002986548,0.000002068654,0.00004305289,0.0000782144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1246045,"threshold_uncertainty_score":0.770564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1186400530557312,"score_gpt":0.4452216757146202,"score_spread":0.326581622658889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}