{"id":"W4385765322","doi":"10.1016/j.omtm.2023.08.004","title":"Selection of viral capsids and promoters affects the efficacy of rescue of Tmprss3-deficient cochlea","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stanford Maternal and Child Health Research Institute; National Center for Research Resources; National Institutes of Health; American Laryngological, Rhinological and Otological Society; American Society of Pediatric Otolaryngology; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Stanford University; National Institute on Deafness and Other Communication Disorders; American College of Surgeons; American Otological Society","keywords":"Cochlea; Capsid; Selection (genetic algorithm); Biology; Promoter; Virology; Gene; Genetics; Virus; Computer science; Neuroscience; Artificial intelligence; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005693915,0.0004286126,0.0004007285,0.0002438042,0.0001684851,0.0004758142,0.0002432554,0.0003236382,0.0006466272],"category_scores_gemma":[0.0004155567,0.0002100437,0.0002449037,0.0001290264,0.000402303,0.0002657697,0.0003285492,0.0005494975,0.0002024927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002502023,"about_ca_system_score_gemma":0.0003011043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000550204,"about_ca_topic_score_gemma":0.0008005088,"domain_scores_codex":[0.999393,0.0001281287,0.00008751694,0.0001128233,0.0001784944,0.0001000241],"domain_scores_gemma":[0.9994943,0.0001770628,0.0001418959,0.00004631406,0.00004129001,0.00009900773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007071139,0.000020791,0.0001292009,0.0000139829,0.000003331642,0.00001883806,0.00001057487,0.00005984493,0.9991384,0.0000210435,0.000007799234,0.0005054176],"study_design_scores_gemma":[0.0000140448,0.0005084215,0.001315652,0.000003508551,0.00001567232,0.0002150035,0.00001447819,0.0005495633,0.996899,0.00001502971,0.0004444103,0.0000052113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966021,0.000727236,0.001902756,0.00004423035,0.00001654363,0.00002760089,0.00008773911,0.00006387339,0.0005279536],"genre_scores_gemma":[0.9963337,0.0005232022,0.002259623,0.00002327991,0.000006812841,0.00002367901,0.0001460324,0.0000430552,0.0006406645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006466272,"threshold_uncertainty_score":0.003011227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1186400530557312,"score_gpt":0.4452216757146202,"score_spread":0.326581622658889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}