{"id":"W4385781150","doi":"10.1016/j.ocarto.2023.100399","title":"Depleting transforming growth factor beta receptor 2 signalling in the cartilage of itga1-null mice attenuates spontaneous knee osteoarthritis","year":2023,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage Open","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Ontario Research Foundation; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Osteoarthritis; Cartilage; Integrin; Chondrocyte; Internal medicine; Downregulation and upregulation; Transforming growth factor beta; Receptor; Endocrinology; Medicine; Chemistry; Cell biology; Biology; Pathology; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008563797,0.0004811751,0.0009669976,0.0002784421,0.0003447171,0.0002576137,0.0004218744,0.0002357455,0.0002761441],"category_scores_gemma":[0.0001151336,0.0004093714,0.0002446514,0.0007564456,0.0001495988,0.0004721394,0.0002135858,0.0003809755,0.00009809517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005410268,"about_ca_system_score_gemma":0.0001111549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001757913,"about_ca_topic_score_gemma":0.002521774,"domain_scores_codex":[0.9966415,0.0002483357,0.0008881288,0.0007385054,0.0006072746,0.0008762658],"domain_scores_gemma":[0.9985845,0.000379673,0.000205011,0.0004287745,0.0001552924,0.000246738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000718082,0.0001522169,0.003240945,0.0002525623,0.00001868353,0.004348823,0.007641167,0.000002550758,0.8050841,0.0004865973,0.0001547284,0.1778995],"study_design_scores_gemma":[0.02531799,0.01630859,0.001134877,0.004474919,0.0004122861,0.003907221,0.01998856,0.00002351137,0.9147592,0.0005074643,0.01171564,0.001449786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881567,0.002944101,0.000004632476,0.0009526876,0.0002335549,0.002774109,0.0003023708,0.0001053795,0.004526406],"genre_scores_gemma":[0.9971521,0.0006391553,0.0003127473,0.0003229316,0.0001587829,0.0003445903,0.0002681178,0.00009284538,0.0007087474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1764498,"threshold_uncertainty_score":0.9998358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01821047687598991,"score_gpt":0.250049202487543,"score_spread":0.2318387256115531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}