{"id":"W4385786732","doi":"10.1101/2023.08.08.552533","title":"Culture substrate stiffness impacts human myoblast contractility-dependent proliferation and nuclear envelope wrinkling","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; St. Michael's Hospital; University of Toronto","funders":"Deutsche Forschungsgemeinschaft","keywords":"Cell biology; Contractility; Myocyte; Laminin; Extracellular matrix; Biology; Cytoskeleton; Fibronectin; Mechanotransduction; Cell; Chemistry; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001106869,0.0001950196,0.0001292478,0.000149863,0.0001214513,0.0002513463,0.00005878939,0.0001353228,0.001509256],"category_scores_gemma":[0.0001593905,0.0001443715,0.0001110902,0.0001315358,0.00009140967,0.0001154019,0.0001651122,0.0001795622,0.0002255812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001205774,"about_ca_system_score_gemma":0.0001029866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009892173,"about_ca_topic_score_gemma":0.001806806,"domain_scores_codex":[0.9998901,0.00002076648,0.00001208462,0.00002048785,0.00003491042,0.00002171875],"domain_scores_gemma":[0.9998831,0.00004065881,0.00003086229,0.00001026977,0.00001820149,0.00001692166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005287136,0.000007729399,0.0007453817,0.00001499228,0.000002852287,0.00001939379,0.00001165364,0.00003827522,0.9986942,0.000003644781,0.000009312524,0.0003996245],"study_design_scores_gemma":[0.000004405113,0.0003221439,0.07090931,0.000009337068,0.0000180511,0.0001222369,0.000112149,0.001065832,0.9267011,0.00001250391,0.000715457,0.00000743727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998131,0.0007377615,0.0003681456,0.00001668442,0.000006732736,0.000007738142,0.000203011,0.000007479422,0.0005214877],"genre_scores_gemma":[0.9979698,0.0004073294,0.0004439104,0.00002027293,0.000003126298,0.00001501015,0.0002395226,0.00000493091,0.0008960039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001509256,"threshold_uncertainty_score":0.005048931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582713435018679,"score_gpt":0.239984493276882,"score_spread":0.2241573589266952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}