{"id":"W4385791542","doi":"10.1158/1078-0432.ccr-23-0370","title":"Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shared Health","funders":"National Institute of Environmental Health Sciences; Cancer Research UK; National Cancer Institute; National Institute for Health and Care Research; Myriad Genetics","keywords":"Carboplatin; Docetaxel; Immune system; Oncology; Medicine; Internal medicine; Breast cancer; Triple-negative breast cancer; Cancer; Chemotherapy; Immunology; Cancer research; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001845353,0.0003653691,0.0007244069,0.000182621,0.0001528327,0.0004713388,0.0002252477,0.0002511688,0.001255479],"category_scores_gemma":[0.001578739,0.0001084104,0.0005649477,0.0002409344,0.0001808102,0.0002266054,0.0002478519,0.0004933679,0.0001315286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000371985,"about_ca_system_score_gemma":0.0004410084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008081156,"about_ca_topic_score_gemma":0.001816716,"domain_scores_codex":[0.9995697,0.0002710266,0.000017152,0.00007092641,0.00004163584,0.00002961645],"domain_scores_gemma":[0.9995307,0.0001656786,0.0001253504,0.00003622511,0.00003892968,0.0001031591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2996258,0.002063076,0.5296167,0.0007301652,0.004966693,0.0001464321,0.0002313579,0.009481763,0.02907514,0.0002246163,0.002906966,0.1209314],"study_design_scores_gemma":[0.01856155,0.03319673,0.9068266,0.00008511075,0.00506668,0.0004867346,0.0001664731,0.02534588,0.006551877,0.001111136,0.002549155,0.00005210129],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983534,0.0005386068,0.0003107713,0.00008130521,0.000006518386,0.00007152717,0.0003913606,0.000009979975,0.0002364735],"genre_scores_gemma":[0.9977577,0.00009722595,0.0005738146,0.00004194089,0.00001653192,0.0001125708,0.0011704,0.0000041664,0.000225669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001845353,"threshold_uncertainty_score":0.009759307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2133847575354404,"score_gpt":0.5400903936612291,"score_spread":0.3267056361257887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}