{"id":"W4385793017","doi":"10.1101/2023.06.06.542948","title":"Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C <sup>+/-</sup> During Development","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital; Simon Fraser University","funders":"Stem Cell Network","keywords":"Hypertrophic cardiomyopathy; Troponin; Internal medicine; Cardiology; Cardiomyopathy; Pathogenicity; Troponin T; Medicine; Biology; Heart failure; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000151847,0.0002966617,0.0001451202,0.0001147997,0.0001314466,0.0002535189,0.0003521013,0.0003105699,0.001250886],"category_scores_gemma":[0.0001552856,0.0001151124,0.0002870215,0.00007249161,0.0001938162,0.0001463551,0.0002240145,0.0002395443,0.0002183578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002054707,"about_ca_system_score_gemma":0.0002217343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0019307,"about_ca_topic_score_gemma":0.001147003,"domain_scores_codex":[0.999948,0.00001094697,0.000003400742,0.00001342094,0.00001471846,0.000009441559],"domain_scores_gemma":[0.9999443,0.000009960072,0.00002554276,0.000003632126,0.000005467088,0.00001103399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003158401,0.00009954515,0.0204881,0.0001306598,0.00008572837,0.001469276,0.00005994344,0.03214758,0.9361057,0.00299398,0.0005196434,0.005584126],"study_design_scores_gemma":[0.0001267322,0.0008608478,0.1342203,0.00006838613,0.0002868773,0.003626421,0.0003206813,0.5590592,0.2925414,0.004426783,0.004377252,0.00008525275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919496,0.0003540379,0.006297399,0.0001270621,0.00001516612,0.00001115176,0.0002725509,0.00008021222,0.0008929298],"genre_scores_gemma":[0.9977486,0.0002027195,0.001505855,0.00002192716,0.000002810897,0.000008990566,0.0001825094,0.00001580652,0.000310751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0019307,"threshold_uncertainty_score":0.004184663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852530482365695,"score_gpt":0.2176859713971515,"score_spread":0.1991606665734945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}