{"id":"W4385798321","doi":"10.4049/jimmunol.2200848","title":"4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2","year":2023,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Science Foundation Ireland; European Research Council; Wellcome Trust; University of Dundee","keywords":"Secretion; Metabolite; Annexin; Dimethyl fumarate; Chemistry; Inflammation; Annexin A1; Effector; Anti-inflammatory; Endogeny; Biochemistry; ABCA1; Pharmacology; Cell biology; Transporter; Biology; Apoptosis; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009405069,0.0002890685,0.0001968527,0.0001562758,0.00009821705,0.0001484251,0.0001219243,0.0003151712,0.001654217],"category_scores_gemma":[0.00009727297,0.00009054819,0.0002687695,0.0001090138,0.000153042,0.0001953325,0.0001612775,0.0002943113,0.0002753051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120179,"about_ca_system_score_gemma":0.0001933861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000682076,"about_ca_topic_score_gemma":0.001280859,"domain_scores_codex":[0.9998984,0.0000195743,0.000009027174,0.00001739814,0.00002605417,0.00002936465],"domain_scores_gemma":[0.9999325,0.0000108537,0.00002400643,0.000006168608,0.00000910213,0.00001743132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000202665,0.00001834018,0.00008169266,0.00002102939,0.000002779597,0.00003049466,0.000005168361,0.00001955201,0.999079,0.00003587345,0.00001395024,0.000489449],"study_design_scores_gemma":[0.00002378627,0.0004480752,0.003304936,0.000003868933,0.00000706466,0.0001299955,0.00002574633,0.0003867897,0.9940036,0.00005585689,0.001607434,0.000002777736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926157,0.002256485,0.003041524,0.0001605139,0.00003924218,0.00003855535,0.000310887,0.00005763442,0.001479521],"genre_scores_gemma":[0.9939248,0.0009668095,0.001711453,0.00009982772,0.00001159067,0.00003623149,0.0003747006,0.000009647656,0.002864886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001654217,"threshold_uncertainty_score":0.005533874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008001182488899802,"score_gpt":0.2248614885399244,"score_spread":0.2168603060510246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}