{"id":"W4385802331","doi":"10.3390/organoids2030011","title":"Incorporating Immune Cells into Organoid Models: Essential for Studying Human Disease","year":2023,"lang":"en","type":"article","venue":"Organoids","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Immune system; Organoid; Biology; Disease; Human disease; Function (biology); Immunology; Cell biology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004031878,0.0003067181,0.0003905494,0.0002081061,0.001104919,0.00005278721,0.0004094638,0.0002369763,0.0001716592],"category_scores_gemma":[0.00009955395,0.000300992,0.0001475918,0.0005252114,0.0001933709,0.000237016,0.0003116093,0.0002770818,0.001098015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006574408,"about_ca_system_score_gemma":0.0002033229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008777154,"about_ca_topic_score_gemma":0.00003189802,"domain_scores_codex":[0.9981816,0.0001288974,0.0004797268,0.0005257273,0.00007151124,0.0006124791],"domain_scores_gemma":[0.999005,0.0001056488,0.0001741406,0.0004873686,0.0001603467,0.00006746177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008246502,0.000128359,0.0003770994,0.0001284829,0.0001100306,0.00001551036,0.001853329,0.00008697889,0.9904826,0.002950535,0.003239796,0.0005447898],"study_design_scores_gemma":[0.002559801,0.000254631,0.0008719991,0.00006881051,0.0001582059,0.000005019546,0.001573599,0.0002142444,0.9741289,0.01125115,0.008272994,0.0006406285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912042,0.0004719765,0.00373106,0.0001534149,0.001743787,0.0006787693,0.000738672,0.0006169752,0.0006611651],"genre_scores_gemma":[0.9931376,0.00003593076,0.0002974696,0.00009088676,0.0002316183,0.00009399234,0.001021982,0.00008751191,0.005003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01635371,"threshold_uncertainty_score":0.9999442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02528746185527625,"score_gpt":0.2555558089989663,"score_spread":0.23026834714369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}