{"id":"W4385802413","doi":"10.1093/cid/ciad379","title":"First Do No Harm? Modeling Risks and Benefits of Challenge Trials for Hepatitis C Vaccine Development","year":2023,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre; University of Toronto","funders":"National Institute on Drug Abuse","keywords":"Medicine; Harm; Vaccine efficacy; Hepatitis A vaccine; Cost–benefit analysis; Vaccination; Intensive care medicine; Hepatitis a virus; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01774379,0.001819995,0.001513681,0.001683578,0.0006248335,0.00317991,0.002778095,0.004025435,0.01128518],"category_scores_gemma":[0.05779912,0.0009581265,0.002749201,0.001050159,0.001733666,0.003142037,0.001729908,0.003550515,0.000816617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005040747,"about_ca_system_score_gemma":0.003506113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01190803,"about_ca_topic_score_gemma":0.007809302,"domain_scores_codex":[0.9910142,0.006928485,0.000181083,0.0005690323,0.000447735,0.000859448],"domain_scores_gemma":[0.9508638,0.04281363,0.003469344,0.0008187289,0.001006626,0.001027751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008652763,0.0001484904,0.008422803,0.0002688957,0.0003032874,0.0002969506,0.0002081802,0.9290528,0.0002312071,0.04486113,0.001754425,0.01358664],"study_design_scores_gemma":[0.0004095743,0.001118938,0.004338974,0.0004226359,0.0005801578,0.0004818122,0.0002592914,0.8904684,0.0003121372,0.09526162,0.00627026,0.00007622275],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5140938,0.0134744,0.3377492,0.02555649,0.0006575227,0.003750872,0.006351935,0.0004997315,0.09786589],"genre_scores_gemma":[0.9692898,0.001728846,0.01811341,0.001082532,0.0001228597,0.001040517,0.0004003328,0.00004804669,0.008173602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01774379,"threshold_uncertainty_score":0.09383929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4066488121697182,"score_gpt":0.4862361458674338,"score_spread":0.07958733369771559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}