{"id":"W4385802459","doi":"10.1093/cid/ciad362","title":"Controlled Human Infection Model for Hepatitis C Virus Vaccine Development: Trial Design Considerations","year":2023,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre Hospitalier de l’Université de Montréal; University Health Network","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; Canadian Association for the Study of the Liver; Johns Hopkins University; Public Health Agency; National Institutes of Health; Public Health Agency of Canada; Gilead Sciences","keywords":"Medicine; Clinical endpoint; Hepatitis C virus; Clinical trial; Hepatitis A vaccine; Immunology; Virus; Virology; Intensive care medicine; Hepatitis a virus; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.162025,0.001619686,0.005667379,0.0008919171,0.001307678,0.003774539,0.002322316,0.005907453,0.006295955],"category_scores_gemma":[0.0857284,0.001060774,0.002759516,0.001159682,0.002439836,0.00308534,0.001427965,0.004988964,0.001197295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001905832,"about_ca_system_score_gemma":0.007672447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005870915,"about_ca_topic_score_gemma":0.001340115,"domain_scores_codex":[0.867704,0.1188069,0.005887483,0.001439255,0.005211422,0.0009509466],"domain_scores_gemma":[0.9137777,0.06177618,0.0085097,0.00729371,0.004886926,0.003755835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.4252502,0.01203144,0.006534078,0.03664211,0.00686363,0.001301396,0.001025811,0.01162201,0.01908152,0.07476015,0.03375106,0.3711366],"study_design_scores_gemma":[0.2674462,0.3456374,0.01019914,0.01286914,0.005257539,0.001515655,0.0004607676,0.01735598,0.01071208,0.05271833,0.2753616,0.000466143],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"methods","genre_scores_codex":[0.05945851,0.06483649,0.2873078,0.0406715,0.01845555,0.5005141,0.002874139,0.001252162,0.0246298],"genre_scores_gemma":[0.1448378,0.01198301,0.2540424,0.01643549,0.004543266,0.5625854,0.0006162616,0.0001620664,0.004794343],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.162025,"threshold_uncertainty_score":0.8568805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2399600868750058,"score_gpt":0.4734826280516982,"score_spread":0.2335225411766924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}