{"id":"W4385827803","doi":"10.1158/1078-0432.ccr-23-0621","title":"Molecular Results and Potential Biomarkers Identified from the Phase 3 MILO/ENGOT-ov11 Study of Binimetinib versus Physician Choice of Chemotherapy in Recurrent Low-Grade Serous Ovarian Cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health; Pfizer","keywords":"Medicine; Neuroblastoma RAS viral oncogene homolog; KRAS; Internal medicine; Oncology; Progression-free survival; Confidence interval; MEK inhibitor; Proportional hazards model; Ovarian cancer; Selumetinib; Chemotherapy; Logistic regression; Cancer; MAPK/ERK pathway; Biology; Colorectal cancer; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001704635,0.0002950544,0.000604914,0.0003933543,0.0001526344,0.0005397008,0.0002241957,0.0003096233,0.001908122],"category_scores_gemma":[0.002684474,0.000150626,0.0005095471,0.0004792837,0.0002109774,0.000397465,0.0001862343,0.0004870995,0.0001784725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006418478,"about_ca_system_score_gemma":0.0004109551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005375278,"about_ca_topic_score_gemma":0.001826163,"domain_scores_codex":[0.9993412,0.0003016019,0.00005710409,0.0001261554,0.0001131139,0.00006092088],"domain_scores_gemma":[0.9985937,0.0004304932,0.0006688419,0.00006488782,0.00008601119,0.000155872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1993388,0.002215378,0.6493797,0.0007921912,0.002003288,0.0002065234,0.0001511272,0.002636709,0.02215799,0.0001792514,0.002189609,0.1187495],"study_design_scores_gemma":[0.008876945,0.03452706,0.9398797,0.00008024547,0.002058255,0.0007201906,0.00009857041,0.002404334,0.007416739,0.0002430049,0.003657049,0.00003776012],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958119,0.001999127,0.0001859268,0.0001092791,0.00001410523,0.00008574239,0.001097652,0.00001158586,0.000684585],"genre_scores_gemma":[0.9976125,0.0002955926,0.0002769394,0.0001199269,0.00001410242,0.00005064011,0.001359967,0.000004134116,0.0002661672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001908122,"threshold_uncertainty_score":0.009015083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2301253681193695,"score_gpt":0.5375087817184303,"score_spread":0.3073834135990608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}